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Publications

All publications from our lab are updated here. The whole list of publications by Prof. H. R. Kaback is linked under "HRK@PUBMED". Publications suggested by Prof. H. R. Kaback which are especially important or interesting results are linked under "selected publications".

Selected Publications

HRK@PUBMED

Jiang X., Andersson M., Chau BT., Wong LY., Villafuerte MK., Kaback HR., 2015. Role of conserved Gly-Gly pairs on the periplasmic side of LacY. Biochemistry. [Epub ahead of print].

Bazzone A., Madej MG., Kaback HR., Fendler K., 2015. pH Regulation of Electrogenic Sugar/H+ Symport in MFS Sugar Permeases. PLoS One. 11(5):e0156392.

Smirnova I., Kasho V., Jiang X., Pardon E., Steyaert J., Kaback HR., 2015. Transient conformers of LacY are trapped by nanobodies. Proc. Nat. Acad Sci. 112(45):13839-44.

Kumar H., Finer-Moore JS., Kaback HR., Stroud RM, 2015. Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site. Proc. Nat. Acad Sci. 112(29):9004-9.

Serdiuk T., Sugihara J., Mari SA., Kaback HR., Müller DJ., 2015. Observing a lipid-dependent alteration in single lactose permeases. Structure. 23(4):754-61.

Hariharan P., Balasubramaniam D., Peterkofsky A., Kaback HR., Guan L., 2015. Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc. Proc. Nat. Acad Sci. 112(8):2407-12.

Kaback HR., 2015. A chemiosmotic mechanism of symport. Proc. Nat. Acad Sci. 112(5):1259-64.

Smirnova I., Kasho V., Jiang X., Pardon E., Steyaert J., Kaback HR., 2014. Outward-facing conformers of LacY stabilized by nanobodies. Proc. Nat. Acad Sci. 111(52):18548-53.

Jiang, X., Villafuerte, MKR., Anderson, M., White, SH., and Kaback, HR., 2014. Galactoside-Binding Site in LacY. Biochemistry, 53(9):1536-43.

Smirnova, I., Kasho, V., and Kaback, HR., 2014. Real-time conformational changes in LacY. Proc. Nat. Acad Sci. 111(23):8440-5.

Serdiuk, T., Madej, MG., Sugihara, J., Kawamura, S., Mari, SA.,  Kaback, HR.,  and Müller, DJ. 2014,  Substrate-induced changes in the structural properties of LacY. Proc. Nat. Acad Sci. 111(16):E1571-80.

Madej, MG., Sun, L., Yan, N., and Kaback, HR. 2014. Functional architecture of MFS D-glucose transporters. Proc. Nat. Acad Sci. 111(7):E719-27.

Kumar, H., Kasho, V., Smirnova, I., Finer-Moore, J., Kaback, HR., and Stroud, RM. 2014. Structure of Sugar-Bound LacY. Proc. Nat. Acad Sci. 111(5):1784-8.

Madej, MG., Kaback, HR. 2014. The Life and Times of Lac Permease: Crystals Ai ‚ Äôt Everything, but They Certainly Do Help. In: Membrane Transporter Mechanism: Ziegler, C. & Kraemer, R., eds. Springer Series in Biophysics Volume 17, pp 121-158.

Madej, MG., and Kaback, HR. 2013. Evolutionary mix-and-match with MFS transporters II. Proc. Nat. Acad Sci. 110(50):E4831-8.

Gaiko, O., Bazzone, A., Fendler, K., Kaback, HR. 2013. Electrophysiological  characterization of uncoupled  mutants of LacY. Biochemistry 52(46):8261-6.

Ethayathulla, AS., Yousef, MS., Amin, A., Hariharan, P., Markham, K., Leblanc,  G.,  Kaback, HR., Guan, L., 2013.Structure-based mechanism for Na+/melibiose symport by MelB. Nature Commun., 5:3009.

Zhu, L., Kaback, HR., Dalbey, RE. 2013. YidiC‚Äîa molecular chaperone for LacY protein folding via the  SecYEG machinery. J of Biological Chemistry, 288(39):28180-94.

Jiang, X., Driessen, A., Feringa, B., Kaback, HR. 2013. The Periplasmic Cavity of LacY Mutant  Cys154‚ÜíGly:How Open is Open? Biochemistry, 52(37):6568-74.           

Smirnova, I., Kasho, V., Sugihara, J., Kaback, HR. 2013. Trp replacements for tightly interacting Gly-Gly pairs in LacY stabilize an outward-facing conformation.  Proc. Nat. Acad Sci. 110(22):8876-81.

Madej, MG., Dang, S., Yan, N., Kaback, HR. 2013. Evolutionary mix-and-matchwith MFS transporters. Proc. Nat. Acad Sci. 110(15);5870-5874.

Smirnova, I., Kasho, V., Sugihara, J., Vázquez-Ibar, J.L., Kaback, HR. 2012. Role of protons in sugar binding to LacY. Proc. Nat. Acad Sci. 109(42):16835- 16840.

Sugihara, J., Sung, L., Yan, N., Kaback, HR.  2012. Dynamics of the L-fucose/H+ symporter revealed by fluorescence spectroscopy. Proc. Nat. Acad Sci. 11;109(37):14847-51.

Madej, MG., Soro, SN., Kaback, HR. 2012. The apo-intermediate in the transport cycle of LacY. Proc. Nat. Acad Sci. 109(44):E2970-8.

Andersson, M., Bondar, N., Freites, A., Tobias, D., Kaback, HR., White, SH. 2012.  Proton-coupled dynamics in lactose permease. Structure, 20(11):1893-904.

Zhou, Y., Jiang, X., Kaback, HR. 2012.  Role of the irreplaceable residues in the LacY alternating access mechanism. Proc. Nat. Acad Sci. 109(31):12438-12442.

Jiang, X., Guan, L., Zhou, Y., Hong, W-X., Zhang, Q., Kaback, HR. 2012. Evidence for an intermediate conformer of LacY.  Proc. Nat. Acad Sci. 190(12):4249-4350.

Sugihara, J., Smirnova, I., Kasho, V., Kaback, HR. 2011. Sugar recognition by CscB and LacY. Biochemistry 50(51):11009-11014.

Smirnova, I., Kasho, V., Kaback, HR. 2011 Lactose Permease and the Alternating Access Mechanism. Biochemistry 50(45):9684-9693.

Zhou Y, Madej G, Guan L, Nie Y, Kaback HR. 2012. An Early Event in the Transport Mechanism of LacY Protein nteraction between helices v and i. J. of Biological Chemistry 286(35):30415-30422.

Smirnova, I., Kasho, V., Sugihara, J., Kaback, HR. 2011.  Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding. Proc. Nat. Acad Sci.  108(37):15147-15151.

Jiang X, Nie Y, Kaback HR. 2011. Site-directed alkylation studies with LacY provide evidence for the alternating access model of transport. Biochemistry 50(10):1634-1640.

Kaback HR, Smirnova I, Kasho V, Nie Y, Zhou Y. 2011. The alternating access transport mechanism in LacY. J. Membr. Biol. 239(1-2):85-93.

Garcia-Celma JJ, Ploch J, Smirnova I, Kaback HR, Fendler K. 2010. Delineating electrogenic reactions during lactose/H+ symport. Biochemistry 27:49(29):6115-6121.

Nie Y, Kaback HR. 2010. Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane. Proc. Nat. Acad Sci. 25:107(21):9903-9908.

Liu Z, Madej MG, Kaback HR. 2010. Helix dynamics in LacY: helices II and IV. J Mol Biol. 26:396(3):617-626.

Smirnova, I., Kasho, V., Sugihara, J., Kaback, H.R. 2009. Probing of the rates of alternating access in LacY with Trp fluorescence. Proc. Nat. Acad Sci. 22:106(51):21561-21566.

Guan, L., Kaback, H.R. 2009. Properties of a LacY efflux mutant. Biochemistry 48(39):9250-9255.

Zhou, Y., Nie, Y.,  Kaback, H.R. 2009. Residues Gating the Periplasmic Pathway of LacY. J Mol Biol.
394(2):219-225.

Smirnova, I., Kasho, V., Sugihara, J., Choe, J.Y., & Kaback, H.R. 2009. Residues in the H+ translocation site define the pKa for sugar binding to LacY. Biochemistry 48(37):8852-8860.

Garcia-Celma, JJ, Smirnova, I., Kaback, H.R., Altenbach, Fendler, K. 2009. Electrophysiological characterization of LacY. Proc Natl Acad Sci. 106:7373-7378.

Nie, Y., Zhou, Y & Kaback, H.R. 2009. Clogging the Periplasmic Pathway in LacY. Biochemistry 48:738-743.

Smirnova I.N., Kasho V., Kaback H.R. 2008 Protonation and sugar binding to LacY. Proc Natl Acad Sci. 105(26):8896-8901.

Nie Y., Sabetford F.E., Kaback H.R. 2008. The Cys154‚ÜíGly mutation in LacY causes constitutive opening of the hydrophilic periplasmic pathway. J Mol Biol. 379:695-703.

Dong Y., Palmer S.R., Hasona A., Nagamori S., Kaback H.R., Dalbey R.E., Brady L.J. 2008. Functional overlap but lack of complete cross-complementation of Streptococcus mutants and Escherichia coli YidC orthologs. J Bacteriol. 190:2458-2469.

Zhou Y., Guan L., Freites J.A., Kaback H.R. 2008. Opening and closing of the periplasmic gate in lactose permease. Proc Natl Acad Sci. 105:3774-3778.

Nie, Y., Ermolova, N. & Kaback, H.R. 2007. Site-directed alkylation of LacY: effect of the proton electrochemical gradient. J Mol Biol. 374(2):358-364.

Smirnova, I., Kasho, V., Choe, J.-Y., Altenbach, C., Hubbell, W. L. & Kaback, H.R. 2007. Sugar binding induces an outward facing conformation of LacY. Proc Natl Acad Sci. 104:16504-16509.

Guan, L., Mirza, O., Verner, G., Iwata, S. & Kaback, H.R. 2007. Structural determination of wild-type lactose permease. Proc Natl Acad Sci. 104:15294-15298.

Guan, L. & Kaback, H.R. 2007. Site-directed alkylation of cysteine to test solvent accessibility of membrane proteins. Nature Protocols 2:2012-2017.

Shimohata, N., Nagamori, S., Akiyama, Y., Kaback, H.R. & Ito, K. 2007. SecY alterations that impair membrane protein folding and generate a membrane stress. J Cell Biol. 176:307-317.

Majumdar, D. S., Smirnova, I., Kasho, V., Nir, E., Kong, X., Weiss, S. & Kaback, H. R. 2007. Single-molecule FRET reveals sugar-induced conformational dynamics in LacY. Proc Natl Acad Sci. 104:12640-12645.

Kaback, H.R., Dunten, R., Frillingos, S., Venkatesan, P., Kwaw, I., Zhang, W. & Ermolova, N. 2007. Site-directed alkylation and the alternating access model for LacY. Proc Natl Acad Sci. 104:491-494.

Smirnova, I.N., Kasho, V.N. & Kaback, H.R. 2006. Direct sugar binding to LacY  measured by resonance energy transfer. Biochemistry 45:15279-15287.

Yiling Nie, Irina Smirnova, Vladimir Kasho & Kaback, H. R. 2006. Energetics of ligand-induced  conformational flexibility in the lactose permease of Escherichia coli. J Biol Chem. 281:35779-35784.

Vadyvaloo, V., Smirnova, I. N., Kasho, V. N. & Kaback, H. R. 2006. Conservation of  residues involved in sugar/H(+) symport by the sucrose  permease of Escherichia coli relative to lactose permease. J Mol Biol. 358:1051-1059.

Kasho, V. N., Smirnova, I. N. & Kaback, H. R. 2006. Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to  actose permease. J Mol Biol. 358:1060-1070.

Mirza, O., Guan, L., Verner, G., Iwata, S. & Kaback, H. R. 2006. Structural evidence for induced fit and a mechanism for sugar/H(+) symport in LacY. EMBO J. 25:1177-1183.

Ermolova, N., Madhvani, R. V. & Kaback, H. R. 2006. Site-directed alkylation of cysteine replacements in the lactose permease of Escherichia coli: helices I, III, VI, and XI. Biochemistry 45:4182-4189.

Guan, L., Smirnova, I. N., Verner, G., Nagamoni, S. & Kaback, H. R. 2006. Manipulating phospholipids for crystallization of a membrane transport protein.  Proc Natl Acad Sci USA 103:1723-1726.

Guan, L. & Kaback, H.R. 2006. Lessons from Lactose Permease. Annu Rev Biophys Biomol Struct. 35:67-91.

Sun, J., Savva, C. G., Deaton, J., Kaback, H. R., Svrakic, M., Young, R. & Holzenburg, A. 2005. Asymmetric binding of membrane proteins to GroEL. Arch Biochem Biophys. 434:352-357.

van Bloois, E., Nagamori, S., Koningstein, G., Ullers, R. S., Preuss, M.,  Oudega, B., Harms, N., Kaback, H. R., Herrmann, J. M. & Luirink, J. 2005. The Sec-independent function of Escherichia coli YidC is evolutionary-conserved and essential. J. Bio. Chem. 280:12996-13003.

Weinglass, A. B., Soskine, M., Vazquez-Ibar, J. L., Whitelegge, J. P., Faull, K. F. Kaback, H. R. & Schuldiner, S. 2005. Exploring the role of a unique carboxyl  residue in EmrE by mass spectrometry. J. Bio. Chem.  280:7487-7492.

Kaback, H.R. 2005. Structure and Mechanism of the Lactose Permease. Compt Rendu BIOLOGIE 328:557-567.

Ermolova, N.V., Smirnova, I.N., Kasho, V.N. & Kaback, H.R. 2005. Interhelical packing modulates conformational flexibility in the lactose permeae of  Escherichia coli. Biochemistry 44:7669-7677.

Vardy, E., Arkin, I. T., Gottschalk, K. E., Kaback, H. R. & Schuldiner, S. 2004. Structural conservation in the major facilitator superfamily as revealed by comparative modeling. Protein Sci. 13:1832-1840.

Vázquez-Ibar, J.L., Guan, L., Weinglass, A.B., Verner, G., Gordillo, R. & Kaback, H.R. 2004. Sugar recognition bythe lactose permease of Escherichia  coli. J. Bio. Chem. 279:49214-49221.

Abramson, J. Iwata, S. & Kaback, H.R. 2004. Lactose permease as a paradigm for membrane transport proteins. Mol Membr Biol. 21:227-236.

Weinglass, A., Whitelegge, J.P., Faull, K.F. & Kaback, H.R. 2004. Monitoring Conformational Rearrangements in the Substrate-binding Site of a Membrane Transport Protein by Mass Spectrometry. J. Bio. Chem. 279:41858-41865.

Guan, L. & Kaback, H.R. 2004. Binding affinity of lactose permease is not altered by the H+ electrochemical gradient. Proc. Nat. Acad. Sci. 101:12148-12152.

Abramson, J., Kaback, H.R. & Iwata, S. 2004. Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily. Curr Opin Struct Biol.  14:413-419.

Nagamori, S., Smirnova, I.N. & Kaback, H.R. 2004. Role of YidC in folding of  polytopic membrane proteins. The Jounal of Cell Biology 165:53-62.

Guan, L. & Kaback, H.R. 2004. Binding Affinity of Lactose Permease is not Altered by the H+ Electrochemical Gradient. Proc. Nat. Acad. Sci. 33:12148-12152.

Vázquez-Ibar, J. L., Guan, L., Svrakic, M. & Kaback, H. R. 2003. Exploiting Luminescence Spectroscopy to Elucidate the Interaction Between Sugar and a Tryptophan Residue in the Lactose Permease of Escherichia  coli. Proc. Nat. Acad Sci. 22:12706-12711.

Abramson, J., Smirnova, I., Kasho, V., Verner, G., Iwata, S. & Kaback, H. R. 2003. The Lactose Permease of Escherichia coli: Overall Structure, the Sugar- Binding Site and the Alternating Access Model for Transport. FEBS Letters 555:96-101.

Guan, L. & Kaback, H. R. 2004. Glucose/Sugar Transport in Bacteria.  Encyclopedia of Biological Chemistry William J. Lennarz & M. Daniel Lane, Editors.

Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H.R. & Iwata, S. 2003. Structure and Mechanism of the Lactose Permease of Escerichia coli. Science 301: 610-615.

Ermolova, N., Guan, L. & Kaback, H. R. 2003. Intermolecular Thiol Cross-Linking Via Loops in the Lactose Permease of Escherichia coli. Biochemistry 100:10187-10192.

Sondej, M., Vázquez-Ibar, J. L., Farshidi, A., Peterkofsky, A. & Kaback, H. R. 2003. Characterization of a Lactose Permease Mutant that Binds IIAGlc in the Absence of Ligand. Biochemistry 42:9153-9159.

Zhang, W., Hu., Y. & Kaback, H. R. 2003. Site-Directed Sulfhydryl Labeling of Helix IX in the Lactose Permease of Escherichia coli. Biochemistry 42:4904-4908.

Nagamori, S., Vázquez-Ibar, J. L., Weinglass, A. B. & Kaback, H. R. 2003. In Vitro Synthesis of Lactose Permease to Probe the Mechanism of Membrane I  insertion and Folding. J. Biol. Chem  278:14820-14826.

Weinglass, A. B., Whitelegge, J. P., Hu, Y., Verner, G. E., Faull, K. F. & Kaback, H. R. 2003. Elucidation of Substrate Binding Interactions in a Membrane Transport Protein by Mass Spectrometry. EMBO 22:1467-1477.

Guan, L., Hu, Y. & Kaback, H. R. 2003. Aromatic Stacking in the Sugar Binding Site of the Lactose Permease. Biochemistry 42:1377-1382.

Smirnova, I. N. & Kaback, H. R. 2003. A Mutation in the Lactose Permease of Escherichia coli that Decrease Conformational Flexibility and Increases Protein Stability. Biochemistry 42:3025-3031.

Guan, L., Sahin-Tóth, M., Kálai, T., Hideg, K. & Kaback, H. R. 2003. Probing the Mechanism of a Membrane Tranport Protein with Affinity Inactivators. J. Biol. Chem 278:10641-10648.

Sorgen, P. L., Hu, Y., Guan, L., Kaback, H. R. & Girvin, M. E. 2002. An Approach to Membrane Protein Structure Without Crystals. Proc. Nat. Acad. Sci. 99:14037-14040.

Sahin-Tóth, M., Gunawan, P., Lawrence, M. C., Toyokuni, T. & Kaback, H. R. 2002. Binding of Hydrophobic D- Galactopyranosides to the Lactose Permease of Escherichia coli. Biochemistry  41:13039-13045.

Guan, L., Sahin-Tóth, M. & Kaback, H. R. 2002. Changing the Lactose Permease of Escherichia coli into a Galactose-Specific Symporter. Proc. Nat. Acad. Sci 99:6613-6618.

Whitelegge, J., Kaback, H. R. & le Coutre, J. 2003. Mass Spectrometry of Membrane Transport Proteins. Transmembrane Transporters Chapter 11. Edited by Michael Quick.

le Coutre, J., Turk, E., Kaback, H.R. & Wright, E. M. 2002. Ligand-Induced Differences in Secondary Structure of the Vibrio parahaemolyticus Na+/Galactose Cotransporter. Biochemistry 41:8082-8086.

Vazquez-Ibar, J. L., Weinglass, A. B. & Kaback, H. R. 2001. Engineering a Terbium-Binding Site into an Integral Membrane Protein for Luminescence Energy Transfer. Proc. Nat. Acad. Sci 99:3487-3492.

Guan, L., Murphy, F.D., & Kaback, H.R. 2001. Surface-Exposed Positions in the Transmembrane Helices of the Lactose Permease of Escherichia coli Determined by Intermolecular Thiol Cross-Linking. Proc. Nat. Acad. Sci. 99:3475-3480.

Sondej, M., Weinglass, A.B., Peterkofsky, A. & Kaback, H.R. 2001. Binding of Enzyme IIAGLC, a Component of the Phosphoenolpyruvate: Sugar Phosphotransferase System, to the Escherichia coli Lactose Permease.  Biochemistry 41:5556-5565.

Weinglass, A.B., Sondej, M. & Kaback, H.R. 2001. Manipulating Conformational Equilibria in the Lactose Permease of Escherichia coli. J. of Mol. Bio 315:561-571.

Zhang, W., Guan, L. & Kaback, H.R. 2001. Helices VII and X in the Lactose Permease of Escherichia coli: Proximity and Ligand-Induced Changes. J. of Mol. Bio. 215:53-62.

Kaback, H.R., Sahin-Tóth, M. & Weinglass, A.B. 2001. The Kamikaze Approach to Membrane Transport. Nature Reviews 2:610-620.

Sahin-Tóth, M., Lawrence, M.C., Nishio, T. & Kaback, H.R. 2001. The C-4 Hydroxyl Group of  Galactopyranosides is the Major Determinant for Ligand Recognition by the Lactose Permease of Escherichia coli. Biochemistry 40:13015-13019.

Guan, L., Weinglass, A.B. & Kaback, H.R. 2001. Helix Packing in the Lactose Permease of Escherichia coli: Localization of Helix VI. J. of Mol. Bio. 312:69-77.

Kwaw, I., Zen, K-C, Hu, Y. & Kaback, H.R. 2001. Site-Directed Sulfhydryl Labeling of the Lactose Permease of Escherichia coli: Helices IV and V Which Contain the Major Determinants for Substrate Binding. Biochemistry 40:10491- 10499.

Sahin-Tóth, M. & Kaback, H.R. 2001. Arg-302 Facilitates Deprotonation of Glu325 in the Transport Mechanismof the Lactose Permease from Escherichia coli. Proc. Nat. Acad. Sci. 98:6068-6073.

Wolin, C. & Kaback, H.R. 2000.  Functional Estimation of Loop-Helix Boundaries in the Lactose Permease of Escherichia coli by Single Amino Acid Deletion Analysis.  Biochemistry 40:1996-2003.

Voss, J., Wu, J., Hubbell, W., Jacques, V., Meares, C. F. & Kaback, H.R.  2000.  Helix Packing in the Lactose Permease of Escherichia coli:  Distances Between Site-Directed Nitroxides and a Lanthanide. Biochemistry 40:3184-3188.

Weinglass, A.B., Smirnova, I.N. & Kaback, H.R. 2000. Engineering Conformational Flexibility in the Lactose Permease of Escherichia coli: Use of Glycine-Scanning Mutagenesis to Rescue Mutant Glu325Asp.  Biochemistry 40:769-776.

Zhang, W. & Kaback, H.R. 2000. Effect of the Lipid Phase Transition on the Lactose Permease from Escherichia coli. Biochemistry 39:14538-14542.

Le Coutre, J. & Kaback, H.R. 2000. Structure Function Relationships of Integral Membrane Proteins:Membrane Transporters vs Channels. Biopolymers (Peptide Science) 55:297-307.

Sahin-Tóth, M., Karlin, A. & Kaback, H.R. 2000. Unraveling the Mechanisms of the Lactose Permease of Escherichia coli. Proc. Nat. Acad. Sci. 97:10729-10732.

Zhao, M., Kálai, T., Hideg, K., Altenbach, C., Hubbell, W. & Kaback, H.R. 2000. Binding of Spin-Labeled Galactosides to the Lactose Permease of Escherichia coli. Biochemistry  39:11381-11388.

Weinglass, A.B. & Kaback, H.R. 2000. The Central Cytoplasmic Loop of the Major Facilitator Superfamily of Transport Proteins Governs Efficient Membrane Insertion. Proc. Nat. Acad. Sci. 97:8938-8943.

Venkatesan, P., Hu, Y. & Kaback, H.R. 2000. Site-Directed Sulfhydryl Labeling of the Lactose Permease of Escherichia coli: Helix X. Biochemistry 39:10656-10661.

Venkatesan, P., Kwaw, I., Hu, Y. & Kaback, H.R. 2000. Site-Directed Sulfhydryl Labeling of the Lactose Permease of Escherichia coli: Helix VII. Biochemistry 39: 10641-10648.

Venkatesan, P., Liu, Z., Hu, Y. & Kaback, H.R. 2000. Site-Directed Sulfhydryl Labeling of the Lactose Permease of Escherichia coli: The N-Ethylmaleimide-Sensitive Face of Helix II. Biochemistry 39:10649-10655.

le Coutre, J., Whitelegge, J.P., Gross, A., Turk, E., Wright, E.M., Kaback, H.R. &Faull, K.F. 2000. Proteomics on Full-Length Membrane Proteins Using Mass Spectrometry. Biochemistry 39:4237-4242.

Sahin-Tóth, M. & Kaback, H.R. 2000. Functional Conservation in the Putative Substrate Binding Site of the Sucrose Permease from Escherichia coli. Biochemistry 39:6170-6175.

Sahin-Tóth, M., Frilingos, S., Lawrence, M.C. & Kaback, H.R. 2000. The Sucrose Permease of Escherichia coli: Functional Significance of Cysteine  Residues and Properties of a Cysteine-less Transporter. Biochemistry 39:6164-6169.

Wolin, C.D. & Kaback, H.R. 2000. Thiol Cross-Linking of Transmembrane Domains IV and V in the Lactose Permease of Escherichia coli. Biochemistry 39:6130-6135.

Heyman, J.B., Pfeiffer, M., Hildebrandt, V., Kaback, H.R., Fotiadis, D., de Groot, B., Engel, A., B√ºldt, G., Oesterhelt, D. & Müller, D.J. 2000. Conformations of the Rhodopsin Third Cytoplasmic Loop Grafted Onto Bacteriorhodopsin. Structure 8: 643-653.

Sahin-Tóth, M., Akhoon, K.M., Runner, J. & Kaback, H.R. 2000. Ligand Recognition by the Lactose Permease of Escherichia coli: Specificity and Affinityare Defined by Distinct Structural Elements of  Galactopyranosides. Biochemistry 39:5097-5103.

Kwaw, I., Sun. J. & Kaback, H.R. 2000. Thiol Cross-Linking of Cytoplasmic Loops in the Lactose  Permease of Escherichia coli. Biochemitry 39:3134-3140.

Wang, Q. & Kaback, H.R. 1999. Location of Helix III in the Lactose Permease of Escherichia coli  as Determined by Site-Directed Thiol Cross-Linking. Biochemistry 38:16777-16782.

Weinglass, A.B. & Kaback, H.R. 1999. Conformational Flexibility of theSubstrate Binding Site in the Lactose Permease of Escherichia coli. Proc. Natl. Acad. Sci. USA 96:11178-11182.

Zhao, M., Zen, K.-C., Hernandez-Borrell, J., Altenbach, C., Hubbell, W.L. & Kaback, H.R. 1999. Nitroxide Scanning Electron Paramagnetic Resonance of Helices IV, V and the Intervening Loop in the Lactose Permease of Escherichia coli. Biochemistry 38: 15970-15977.

Whitelegge, J.P., le Coutre, J., Lee, J.C., Engel, C.K., Privé, G.G., Faull, K.F., & Kaback, H.R. 1999. Towards the Bilayer Proteome: Electrospray-Ionization Mass Spectrometry of Large Intact Transmembrane Proteins. Proc. Natl. Acad. Sci. USA 96:10695-10698.

Wang, Q. & Kaback, H.R. 1999. Proximity Relationships Between Helices I and XI or XII in the LactosePermease of Escherichia coli Determined by Site-Directed Thiol Cross-Linking. J. of Mol. Biol.  291:683-692.

Michel Julien, Shama Kajiji, Ronald H. Kaback, and Philippe Gros.  2000. Simple Purification of Highly Active Biotinylated P-Glycoprotein: Enantiomer-Specific Modulation of Drug-Stimulated ATPase Activity.  Biochemistry 39: 75-85.

Wolin, C. & Kaback. H.R. 1999. Estimating loop-helix interfaces in a polytopic membrane protein by deletion analysis. Biochemistry 38:8590-8597.

Zhao, M., Zen, K.-C., Hubbell, W. & Kaback, H.R. 1999. Proximity between Glu126 and Arg144 in the Lactose Permease of Escerichia coli. Biochemistry 38:7407-7412.

Kaback, H. R. & Wu, J. 1999.  The Lactose Permease of Escherichia coli: What to do While Awaiting Crystals of a Membrane Transport Protein. Acc. Chem. Res. 32:805-813.

Sondej, M., Sun, J., Seok, Y-J., Kaback, H. R., & Peterkofsky, A. 1999. Deduction of a Consensus Binding Sequence for IIAGlc of the Phosphoenolpyruvate:sugar Phosphotransferase System by Cysteine Scanning  Mutagenesis of Escerichia coli Lactose Permease. Proc. Natl. Acad. Sci. USA 96:3525-3530.

Wang, Q. & Kaback, H. R. 1998 Helix packing in the lactose permease of Escherichia coli determined by site-directed thiol crosslinking: helix I is close to helices V and XI. Biochemistry 38:3120-3126.

Sun, J., Voss, J., Hubbell, W. & Kaback, H. R. 1998.  Proximity betweenPeriplasmic Loops in the Lactose Permease of Escherichia coli  as determined by Site-Directed Spin Labeling. Biochemistry 38:3100-3105.

Wu, J., Hardy, D. & H. Ronald Kaback, 1998.  Site-Directed Chemical Crosslinking Demonstrate that Helix IV is Close to Helices VII and XI in the Lactose Permease. Biochemistry 38:1715-1720.

Wu, J., Hardy, D., & Kaback, H.R., 1998.  Tertiary Contacts of Helix V in the Lactose Permease Determined by Site-Directed Chemical Crosslinking in situ. Biochemistry 38:2320-2325.

Sahin-Tóth, M., le Coutre, J., Kharabi, D., le Maire, G., Lee, J. & Kaback, H.R. 1998.  Characterization of Glu126 and Arg144, Two Residues that are Indispensable for Substrate Binding in the Lactose Permease of Escherichia coli. Biochemistry 38: 813-819.

Pouny, Y., Weitzman, C., & Kaback, H.R., 1998.  In vitro  Biotinylation Provides Quantitative Recovery of Highly Purified Active Lactose Permease in a Single Step.  Biochemistry 37:15713-15719.

Venkatesan, P., & Kaback, H.R., 1998.  The Substrate Binding Site in the Lactose Permease of Escherichia coli.  Proc. Natl. Acad. Sci. USA 95:9802-9807.

Wu, J., Hardy, D., & Kaback, H.R., 1998.  Tilting of Helix I and Ligand-Induced Changes in the Lactose Permease Determined by Site-Directed Chemical Crosslinking in situ. Biochemistry 37:15785-15790.

Frilingos, S., Sahin-Tóth, M., Wu, J., & Kaback, H.R., 1998.  Cys-Scanning Mutagenesis: a Novel Approach to Structure-Function Relationships in Polytopic Membrane Proteins. FASEB Journal  12:1281-1299.

Wu, J., Hardy, D, & Kaback, H. R., 1998.  Transmembrane Helix Tilting and Ligand-Induced Conformational Changes in the Lactose Permease Determined by Site-Directed Chemical Crosslinking In Situ. Journal of  Molecular Biology 282:959-967.

Zhuang, J., Privé, G., Werner, G., Ringler, P., Kaback, H. R., & Engel, Andreas, 1998.  Two-Dimensional Crystallization of the Escherichia Coli  Lactose Permease. Journal of Structural Biology 125:63-75.

le Coutre, J., Kaback, H.R., Patel, C. Kumar N., Heginbotham, L, & Miller, Christopher, 1998.  Fourier Transform Infrared Spectrosopy Reveals a Rigid a-helical Assembly for the Tetrameric Streptomyces  Lividans K+  Channel. Proc. Natl. Acad. Sci. USA 95: 6114-6117.

Voss, J., Sun, J., Venkatesan, P., & Kaback, H.R. 1998.  Sulfhydryl Oxidation of Mutants with Cysteine in Place of Acidic Residues in the Lactose Permease. Biochemistry  37:8191-8196.

Sun, J., Kemp, C. R. & Kaback, H. R. 1998.  Ligand-Induced Changes in Periplasmic Loops in the Lactose Permease of Escherichia coli. Biochemistry 37:8020-8026.

Wang, Q., Voss, J., Hubbell, W. L., & Kaback, H. R. 1998.  Proximity of Helices VIII (Ala273) and IX (Met299) in the Lactose Permease of Escherichia coli. Biochemistry  37:4910-4915.

Frilingos, S., Gonzalez, A., & Kaback, H.R. 1997.  Cysteine-Scanning Mutagenesis of Helix IV and the Adjoining Loops in the Lactose Permease of Escherichia coli:  Glu126 and Arg144 Are Essential.  Biochemistry36:14284-14290.

Kaback, H.R. 1997.  Structure/Function Studies on the Lactose Permease of Escherichia coli.  Acta  Physiologica Scandinavica 163:21-33.

Kaback, H.R. & Wu, J. 1997. From Membrane to Molecule to the Third Amino Acid from the Left with the Lactose Permease of Escherichia coli. Quarterly Reviews of Biophysics  30:333-364.

Voss, J., Hubbell, W. & Kaback, H. R. 1998. Helix Packing in the Lactose Permease Determined by Metal-Nitroxide Interaction. Biochemistry  37:211-216.

Voss, J., Hubbell, W., Hernandez-Borrell, J. & Kaback, H. R. 1997. Site-Directed  Spin-Labeling of Transmembrane Domain VII and the 4B1 Antibody Epitope in the Lactose Permease of Escherichia coli. Biochemistry  36:15055-15061.

He, M. & Kaback, H. R. 1997. In Vitro Folding of a Membrane Protein: Denaturation and Renaturation of Substrate Binding by the Lactose Permease of Escherichia coli. Membrane Molecular Biology  15:15-20.

Wang, Q., Matsushita,K., de Foresta, B., LeMaire, M & Kaback, H.R. 1997. Ligand-Induced Movement of Helix X in the Lactose Permease of Escherichia coli: a Fluorescence Quenching Study. Biochemistry  36:14120-14127.

Seok, Y-J., Sun, J., Kaback, H.R. & Peterkofsky, A. 1997. Topology of Allosteric Regulation of Lactose Permease. Proc. Natl. Acad. Sci. USA  94:13515-13519.

He, M. & Kaback, H. R. 1997. Interaction between Residues Glu269 (Helix VIII) and His322 (Helix X) of the Lactose Permease of Escherichia coli  is Essential for Substrate Binding. Biochemistry  36:13688-13692.

He, M., Voss, J.,Hubbell, W.  & Kaback, H.R. 1997. Arginine 302 (Helix X) in the Lactose Permease of Escherichia coli  is in Close Proximity to Glutamate 269 (Helix VIII) as well as Glutamate 325 (Helix X).  Biochemistry  36:13682-13687.

le Coutre, J., Narasimhan, L.R., Patel, C.K.N. & Kaback, H. R. 1997. The Lipid Bilayer Determines Helical Tilt Angle and Function in Lactose Permease of  Escherichia coli--an ATR-FTIR study. Proc. Natl. Acad. Sci. USA  94:10167-10171.

Kaback, H.R., Voss, J. & Wu, J. 1997. Helix Packing in Polytopic Membrane Proteins: the Lactose Permease of Escherichia coli . Current Opinion in Structural Biology 7: 537-542.

Sun, J. & Kaback, H. R. 1997. Proximity of Periplasmic Loops in the Lactose Permease of Escherichia coli Determined by Site-Directed Crosslinking. Biochemistry  36:11959-11965.

Merickel, A., Kaback, R. & Edwards, R. 1997. Charged Residues in Transmembrane Domains II and XI of a Vesicular Monoamine Transporter Form a Charge Pair that Promotes High Affinity Substrate Recognition. The Journal of Biological Chemistry  272:5403-5408.

Kaback, H. R. 1997. A Molecular Mechanism for Energy Coupling in a Membrane Transport Protein, the Lactose Permease of Escherichia coli. Proc. Natl. Acad. Sci. USA  94:5539-5543.

Frilingos, S., Wu, J., Venkatesan, P. & Kaback, H.R. 1997. Binding of Ligand or Monoclonal Antibody 4B1 Induces Discrete Structural Changes in the Lactose Permease of Escherichia coli. Biochemistry  36:6408-6414.

Sun, J., Frillingos, S. & Kaback, H. R. 1997. Binding of Monoclonal Antibody 4B1 to Homologs of the Lactose Permease of Escherichia coli. Protein Science 6:1503-1510.

Wu, J. & Kaback, H.R. 1997. Helix Proximity and Ligand-Induced Conformational Changes in the Lactose Permease of Escherichia coli  Determined by Site-Directed Chemical Crosslinking. The Journal of Molecular Biology 270:285-293.

Wu., J. & Kaback, H.R. 1997. A General Method for Determining Helix Packing in Membrane Proteins in situ: Helices I and II are close to Helix VII in the Lactose Permease of Echerichia coli. Proc. Natl. Acad. Sci. USA 93:14498-14502.

Frillingos, S. & Kaback, H.R. 1997. The Role of Helix VIII in the Lactose Permease of Echerichia coli. II: Site-Directed Sulfhydryl Modification. Protein Science   6:438-443.

Frillingos, S., Ujwal, M. L., Sun, J., & Kaback, H.R. 1997. The Role of Helix VIII in the Lactose Permease of Escherichia coli. I: Cys-scanning Mutagenesis. Protein Science  6:431-37.

Sun, J., Li, J., Carrasco, N. & Kaback, H.R. 1997. The Last Two CytoplasmicLoops in the Lactose Permease of Escherichia coli Comprise a Discontinuous Epitope for Monoclonal Antibody 4B11. Biochemistry  36:274-280.

Frillingos, S., Sun, J., Gonzalez, A. & Kaback, H.R. 1996. Cysteine Scanning Mutagenesis of Helix II and Flanking Hydrophilic Domains in the Lactose Permease of Escherichia coli. Biochemistry  36:269-273.

Braun, P., Persson, B., Kaback, H.R., & von Heijne, G. 1997. Alanine Insertion Scanning Mutagenesis of Lactose Permease Transmembrane Helices.  J. Biol. Chem. 272:29566-29571.

Pourcher, T. , Bibi, E, Kaback, H.R.., Leblanc, G. 1996. Membrane Topology of the Melibiose Permease of Escherechia coli studied by Mel B- pho A Fusion Analysis.  Biochemistry  35:4161-4168.

Frillingos, S. & Kaback, H.R. 1996. Chemical Rescue of Asp237-> Ala and Lys358-> Ala Mutants in the Lactose Permease of Escherichia coli. Biochemistry  35:13363-13367.

Wu, J., Voss, J., Hubbell, W.L., Kaback, H.R., 1996. Site-Directed Spin Labeling and Chemical Crosslinking Demonstrate that Helix V is Close to Helices VII and VIII in the Lactose Permease of Escherichia coli. Proc. Natl.Acad. Sci. USA  93:10123-10127.

Frillingos, S. & Kaback, H.R., 1996 Monoclonal Antibody 4B1 Alters the pKa of a Carboxylic Acid at Position 325 (helix X) of the Lactose Permease of Escherichia coli.  Biochemistry  35:10166-10171.

Voss, J.,He, M.M., Hubbell,W.L., & Kaback, R.H., 1996 Site-Directed Spin-Labeling Demonstrates that Transmembrane Domain XII in the Lactose Permease of Escherichia coli is an a- Helix. Biochemistry 35:12915-12918.

He, M.M., Sun, J., Kaback, H.R.,  1996 Cysteine-Scanning Mutagenesis of Transmembrane Domain XII and the Flanking Periplasmic Loop in the Lactose Permease of Escherichia coli .  Biochemistry  35:12909-12914.

Bogdanov, M., Sun, J. Kaback, H.R., & Dowhan, W 1996. A Phospholipid Acts as a Chaperone in Assembly of Membrane Transport Protein. Journal of  Biological Chemistry  271:11615-11618.

Wu, J., Sun, J., & Kaback, H.R., 1996. Purification and Functional Characterization of the C-Terminal Half of the lactose permease of Escherichia coli. Biochemistry  35: 5213-5219.

Frillingos, S., & Kaback, H.R., 1996. Cysteine-scanning Mutagenesis of Helix VI and the Flanking Hydrophilic Domains in the Lactose Permease of Escherichia coli. Biochemistry  35:5333-5338.

Sahin-Tóth,M., Kaback, H.R. & Friedlander, M., 1996. Association Between the Amino Acid Carboxyl  Terminal Halves of Lactose Permease is Specific and Mediated by Multiple Transmembrane Domains. Biochemistry 35:2016-2021.

Frillingos,S. & Kaback, H.R., 1995. Probing the Conformation of the Lactose Permease of Escherichia coli by in situ Site-Directed Sulfhydryl Modification. Biochemistry  35:3950-3956.

Kaback, H.R., 1996. In The Handbook of Biological Physics:  Transport Processes in Eukaryotic and Prokaryotic Cells, Vol. II.  The Lactose Permease of Escherichia coli: Past, Present and Future.  W. N. Konings,H. R. Kaback & J. S. Lolkema, eds.  Elsevier, Amsterdam, pp. 203-227.

Voss, J., Hubbell, W., & Kaback, R.H. 1995. Distance Determination in Proteins Using Metal Ion Binding Sitesand Site-Directed Spin-Labeling: II. Application to the Lactose Permease of Escherichia coli. Proc. Natl. Acad. Sci. USA  92:12300-12303.

Voss, J.,  Salwinski, L., Kaback, H.R., & Hubbell, W., 1995. A Method for Distance Determination in Proteins Using a Designed Metal Ion Binding Site-Directed Spin-Labeling: I. Evaluation with T4 Lysozome. Proc. Natl.  Acad. Sci. USA  92:12295-12299.

Sun, J.; Wu, J., Carrasco, N. & Kaback, H.R., 1995. Identification of the epitope for monoclonal antibody 4B1 which uncouples lactose and proton translocation in the lactose permease of Escherichia coli. Biochemistry 35:990-998.

He, M.M. Voss, J., Hubbell, W.L., & Kaback, H.R., 1995.  Use of designed metal binding sites to study helix proximity of lac permease of Escherichia coli:  II. Proximity of Helix IX (Arg 302) with Helix X (His 322 and Glu 325). Biochemistry 34:15661-15666.

He, M.M., Voss, J., Hubbell, W.L. & Kaback, H.R., 1995. Use of designed metal binding sites to study helix proximity in the lactose permease of Escherichia coli: I. Proximity of Helix VII (Asp 237 and Asp 240) with Helix X (lys 319) and XI (lys 358). Biochemistry  34:15667-15670.

Weitzman, C., Consler, T.G. & H.R. Kaback.  1995.  Fluorescence of Native Single-Trp Mutants in the Lactose Permease of Escherichia coli:  Structural Properties and Evidence for a Substrate-Induced Conformational Change.  Protein Science 4:2310-2318.

Wu, J. Perrin, D.M., Sigman, D.S. & H. R. Kaback.  1995.  Helix Packing of Lactose Permease in Escherichia coli Studied by Site-Directed Chemical Cleavage. Proc. Natl. Acad. Sci. USA 92:9186-9190.

Voss, J., Hubbell, W.L. & H.R. Kaback. 1995 Distance determination in proteins using designed metal ion binding sites and site-directed spin labeling.  Biophys. J. 68: A423.

Frilingos, S., Sahin-Tóth, M., Lengeler, J.W. & H.R. Kaback.  1995.  Helix packing in the sucrose permease of Escherichia coli:  Properties of engineered charge pairs between helices VII and XI.  Biochemistry 34:9368-9373.

Privé, G.G. & H.R. Kaback.  1996.  Engineering the lac permease for purification and crystallization. J Bioenergetics and Biomembranes 28:29-34.

Weitzman, C. & H.R. Kaback.  1995.  Cysteine Scanning Mutagenesis of Helix V in the Lactose Permease of Escherichia coli.  Biochemistry   34:9374-9379.

Wu, J., Frilingos, S. & H.R. Kaback.  1995.  Dynamics of Lactose Permease of Escherichia coli Determined by Site-Directed Chemical Labeling and Fluorescence Spectroscopy.  Biochemistry  34:8257-8263.

Jung, K., Voss, J. He, M., Hubbell, W.L. & H.R. Kaback. 1995.  Engineering a metal binding site within a polytopic membrane protein, the lactose permease of Escherichia coli.  Biochemistry  34:6272-6277.

Sahin-Tóth,M., Frilingos, S., Lengeler, J.W. & H.R. Kaback. 1995.  Active Transport by the cscB Gene Product in Escherichia coli. K-12.  Biochemical Biophysical Research Communications 208(3):1116-1123.

Ujwal, M.L., Jung, H., Bibi, E., Altenbach, C. Maniol, C., Hubbell, W. & H. R. Kaback.  1995.  Membrane Topology of Helices VII and XI in the Lactose Permease of Escherichia coli. Studied by LacY-phoA Fusion Analysis and Site-Directed Spectroscopy. Biochemistry 34:14909-14917.

Zen, K.H., Consler, T.G. & H.R. Kaback. 1995.  Insertion of the polytopic membrane protein lactose permease occurs by multiple mechanisms. Biochemistry 34:3430-3437.

Sahin-Tóth,M., Dunten, R.L. & H.R. Kaback.  1995.  Design of a membrane protein for site-specific proteolysis: properties of engineered factor Xa protease sites in the lactose permease of Escherichia coli.  Biochemistry,  Accelerated Publication 34: 1107-1112.

Kaback, H.R. 1995.  The Lactose Permease of Escherichia coli:  An Update.  Physiology of Membrane Disorders (Joseph Hoffman, ed.) Chap. 6, pp. 111-128.

Jung, K., Jung, H., Colacurcio, P. & H.R. Kaback. 1995.  Role of Glycine Residues in the Structure and Function of Lactose Permease, an Escherichia coli Membrane Transport Protein.  Biochemistry 34:1030-1039.

Wu, J., Frilingos, S., Voss, J. & H.R. Kaback.  1994.  Ligand-induced conformation changes in the lactose permease of Escherichia coli:  evidence for  two binding sites.  Protein Science 3:2294-2301.

Sahin-Tóth,M., Frilingos, S., Bibi, E., Gonzalez, A. & H.R. Kaback.  1994.  The role of transmembrane domain III in the lactose permease of Escherichia coli. Protein Science 3:2302-2310.

Kaback, H.R., Frilingos, S., Jung, H., Jung, K., Privé, G.G., Ujwal, M.L., Weitzman, C., Wu, J., & K. Zen.  1994.  The lactose permease meets Frankenstein. J. Experimental Biology (William Harvey, ed.) London, 196:183- 195.

Wu, J. & H.R. Kaback.  1994.  Cysteine 148 in the lactose permease of Escherichia coli is a component of a substrate binding site.  II.  Site-directed fluorescence studies.  Biochemistry 33:12166-12171.

Jung, H., Jung, K., & H.R. Kaback.  1994.  Cysteine 148 in the lactose permease of Escherichia coli is acomponent of a substrate binding site.  I.  Site-directed mutagenesis studies.  Biochemistry 33:12160-12165.

Jung, H., Jung, K. & H.R. Kaback.  1994.  A conformational change in the lactose permease of Escherichia coliis induced by ligand binding or membrane potential. Protein Science 3(7):1052-1057.

Frilingos, S., Sahin-Tóth, M., Persson, B. & H.R. Kaback.  1994.  Cysteine-scanning mutagenesis of putative helix VII in the lactose permease of Escherichia coli.  Biochemistry 33:8074-8081.

Zen, K. H., McKenna, E., Bibi, E., Hardy, D. & H.R. Kaback.  1994.  Expression of lactose permease in contiguous fragments as a probe for membrane-spanning domains.  Biochemistry 33:8198-8206.

Sahin-Tóth, M., Lawrence M.C. & H.R. Kaback.  1994.  Properties of permease dimer, a fusion protein containing two lactose permease molecules from Escherichia coli..  Proc. Natl. Acad. Sci. USA 91:5421-5425.

Jung, K., Jung H. & H.R. Kaback.  1994.  Dynamics of Lactose Permease of Escherichia coli determined by Site-Directed Fluorescence Labeling. Biochemistry 33:3980-3985.

Kaback, H.R., Jung, K., Jung, H., Wu, J., Privé, G.G., & K. Zen.  1995.  Helix Packing in the C-Terminal Half of Lactose Permease.  in  Cell Biology in Membrane Organization and Biogenesis in Prokaryotic Organisms (R.E.  Dalbey, ed.) JAI press, Inc., pp. 129-144.

Sahin-Tóth, M., Persson, B., Schwieger, J., Cohan, M. & H.R. Kaback.  1994.  Cysteine Scanning Mutagenesis of the N-terminal 32 Amino Acid Residues in the Lactose Permease of Escherichia coli.  Protein Science 3:240-247.

Privé, G.G., Verner, G.E., Weitzman, C., Zen, K.H., Eisenberg, D. & H.R. Kaback.  1994.  Fusion Proteins as Tools for Crystallization:  The Lactose Permease of Escherichia coli.  Acta Cryst. D50:375-379.

Dunten, R.L., Sahin-Tóth, M. & H.R. Kaback.  1993.  Cysteine Scanning Mutagenesis of Putative Helix XI in the lactose permease of Escherichia coli. Biochemistry  32: 12644-12650.

Kaback, H.R., Jung, K., Jung, H., Wu, J., Privé, G.G., & Zen, K.H.  1993. What's New with Lactose Permease.  J Bioenergetics and Biomembranes 25:627-636.

Jung, K., Jung, H., Wu, J. Privé, G.G., & H.R. Kaback.  1993.  Use of Site-Directed Fluorescence Labeling to Study Proximity Relationships in the Lactose Permease of Escherichia coli.  Biochemistry 32:12273-12278.

Sahin-Tóth, M. & H.R. Kaback.  1993.  Cysteine scanning mutagenesis of putative transmembrane helices IX and X in the lactose permease of Eschericnia coli.  Protein Science 2:1024-1033.

van Iwaarden, P.R., Driessen, A.J.M., Lolkema, J.S., Kaback, H.R. & Konings, W.N.  1993.  Exchange, Efflux and Substrate Binding by Cysteine Mutants of the  Lactose Permease of Escherichia coli.  Biochemistry 32:5419-5424.

Sahin-Tóth, M. & H.R. Kaback.  1993.  Properties of interacting aspartic acid and lysine residues in the lactose permease of Escherichia coli.  Biochemistry 32:10027-10035.

Consler, T.G., Persson, B.L., Jung, H., Zen, K.H., Jung, K. Privé, G.G., Verner, G.E. & H. R. Kaback.  1993.  Properties and purification of an active biotinylated lactose permease from Escherichia coli.  Proc. Natl. Acad. Sci. USA 90:6934-6938.

Sahin-Tóth, M. Dunten, R.L. & H.R. Kaback.  1993.  The Lactose Permease of Escherichia coli:  A Paradigm for Membrane Transport Proteins.  In  "Molecular Biology and Function of Carrier Proteins" (L. Reuss, J.M.  Russell, Jr. & M.L. Jennings, eds.) The Rockefeller University Press, Chap. 1, pp. 1-9.

Li, T., Krasne, S.J., Persson, B., Kaback, H.R. & Diederich, F.  1993.  Carriers for Nucleotide 5'-Triphosphates.  2.  Liquid Membrane and Liposome Transport.  J. Org. Chem. 58:380-384.

Ujwal, M.L., Sahin-Tóth, M., Persson, B., & H.R. Kaback.  1994.  Role of glutamate 269 in the Lactose Permease of Escherichia coli.  Molecular Membrane Biology 1: 9-16.

Dunten, R.L., Sahin-Tóth, M. & H.R. Kaback.  1992.  Role of the Charge Pair Formed by Aspartic Acid 237 and Lysine 358 in the Lactose Permease of Escherichia coli.  Biochemistry 32:3139-3145.

Bibi, E., Talbot, F., Gros, P. & H.R. Kaback. 1993.  Functional Expression of mouse multidrug resistance protein in Escherichia coli.  Proc. Natl. Acad. Sci. USA 90(19): 9209-9213.

McKenna, E., Hardy, D. & H.R. Kaback.  1992.  Insertional Mutagenesis of Hydrophilic Domains in the Lactose Permease of Escherichia coli.  Proc. Natl. Acad. Sci. USA 89:11954-11958.

Sahin-Tóth, M., Dunten, R.L., Gonzalez, A. & H.R. Kaback.  1992.  Functional Interactions Between Putative Intramembrane Charged Residues in the Lactose Permease of Escherichia coli.  Proc. Natl. Acad. Sci. USA  89:10547-10551.

Persson, B., Roepe, P.D., Patel, L., Lee, J. & H.R. Kaback. 1992.  Site-Directed Mutagenesis of Lysine 319 in the Lactose Permease of Escherichia coli. Biochemistry 31:8892-8897.

H.R. Kaback. 1992.  The Lactose Permease of Escherichia coli:  A Paradigm for Membrane Transport Proteins.  Biochim. Biophys. Acta  1101:210-213.

Bibi, E. & H.R. Kaback. 1992.  Recent Studies on the Lactose Permease of Escherichia coli.  In:  "Molecular Mechanisms of Transport" (E. Quagliariello, F. Palmieri, eds.), Elsevier Science Publishers, B.V., pp. 175-179.

Bibi, E., Stearns, S.M. & H.R. Kaback. 1992.  The N-terminal Twenty-two Amino Acid Residues in the Lactose Permease of Escherichia coli are not Obligatory for Membrane Insertion or Transport Activity.  Proc. Natl. Acad.  Sci. USA 89:3180-3184.

McKenna, E., Hardy, D. & H.R. Kaback.  1992.  Evidence that the Final Turn of the Last Transmembrane Helix in the Lactose Permease is Required for Folding. J. Biol. Chem. 267:6471-6474.

Bibi, E. & H.R. Kaback.  1992.  Functional Complementation of Internal Deletion Mutants in the Lactose Permease of Escherichia coli.  Proc. Natl. Acad. Sci. USA  89:1524-1528.

H.R. Kaback.  1992.  In and Out and Up and Down with the Lactose Permease of  Escherichia coli.  In, "Bacterial and Glucose Transporters" (M. Friedlander & M. Mueckler, eds.) International Review of Cytology:  A Survey of Cell Biology, 137 (Part A): 97-125.

H.R. Kaback.  1992.  Beta-Galactoside Transport in Escherichia coli:  The Ins and Outs of Lactose Permease.  In "Dynamics of Membrane Assembly" NATO ASI Series Springer-Verlag, New York, H63: 293-308.

Gros, P. Talbot, F. Bibi, E. & H.R. Kaback. 1992.  Lipophilic Cations:  A Group of Model Substrates for the Multidrug Resistance Transporter.  Biochemistry 31:1992-1998.

Pourcher, T., Bassilana, M. Sarkar, H.K., H.R. Kaback, & Leblanc, G. 1992. Melibiose Permease of Escherichia coli:  Mutation of Histidine-94 Alters Expression and Stability Rather than Catalytic Activity.  Biochemistry  31:5225-5231.

van Iwaarden, P.R., Pastore, J.C., Konings, W.N. & Kaback, H.R.  1991. Construction of a Functional Lactose Permease Devoid of Cysteine Residues.  Biochemistry  30: 9595-9600.

Bibi, E., Verner G., Chang, C-Y. & Kaback, H.R.  1991.  Organization and Stability of a Polytopic Membrane Protein:  Deletion Analysis of the Lactose Permease of Escherichia coli.  Proc. Natl. Acad. Sci. USA 88:7271-7275.

McKenna, E., Hardy, D. Pastore, J.C. & Kaback, H. R.  1991. Sequential Truncation of the Lactose Permease over a Three Amino-Acid Sequence Near the Carboxyl-Terminus Leads to Progressive Loss of Activity and Stability. Proc. Natl. Acad. Sci. USA 88:2969-2973.

van Iwaarden, P.R., Driessen, A.J.M., Menick,  D.R., Kaback, H.R. & Konings, W.N. 1991.  Characterization of Purified, Reconstituted Site-Directed Cysteine Mutants in the Lactose Permease of Escherichia coli.  J. Biol.  Chem. 266(24):15688-15692.

Hinkle, P.C., Hinkle, P.V. & Kaback, H.R. 1990.  Information Content of Amino Acid Residues in Putative Helix VIIIof lac Permease from Escherichia coli. Biochemistry 29:10989-10994.

Consler, T.G., Tsloas, O. & Kaback, H.R. 1991.  Role of Proline Residues in the Structure and Function of a Membrane Transport Protein.  Biochemistry 30:1291-1298.

Lolkema, J.S., Carrasco, N. & Kaback, H.R. 1991.  Kinetic Analysis of Lactose Exchange in Proteoliposomes Reconstituted with Purified Lac Permease. Biochemistry  30:1286-1290.

Roepe, P.D. & Kaback, H.R. 1990.  The lac permease of Escherichia coli:  A Protytype Transport Protein. J.M. Ritchie, P.J. Magistretti & L. Bolis (Eds.) Progress in Cell Research 1:213-229.

Kaback, H.R. 1990.  The lac permease of Escherichia coli:  A Prototypic Energy- Transducing Membrane Protein.  Biochim. Biophys. Acta  1018:160-162.

Kaback, H.R., Bibi, E. & Roepe, P.D. 1990.  Beta-Galactoside Transport in Escherichia  coli:  A Functional Dissection of Lac  Permease.   Trends In Biochem. Sci. 15(8):309-314.

Bibi, E. & Kaback, H.R. 1990.  In Vivo  Expression of the LacY  Gene in Two Segments Leads to Functional Lac Permease.  Proc. Natl. Acad. Sci. USA 87:4325-4329.

Roepe, P.D. & Kaback, H.R.  1990.  Chapter 7.  The use of site-directed mutagenesis to investigate secondary active transport.  In Biomembranes and Bioenergetics  (Malcolm Page an d P.J.F. Henderson, eds.) CRC Critical Reviews in Biochemistry.

Roepe, P.D. & Kaback, H.R., & Page, M.G.P. 1990.  Chapter 3.  Identification   and Purification of Sugar Transport Proteins. In Biomembranes and Bioenergetics  (Malcolm Page an d P.J.F. Henderson, eds.) CRC Critical   Reviews in Biochemistry.

Roepe, P.D. Consler, T.G., Menezes, M.E. & Kaback, H.R. 1990.  The lac permease of Escherichia coli:  Site-Directed Mutagenesis Studies on the Mechanism of B-Galactoside/H+ Symport.  Submitted Res. in  Microbiology (Annales de l'Institute Pasteur)  Ed. Milton H. Saier, Vol 141(3):290-308.

Menezes, M.E., Roepe, P.D., Kaback, H.R. 1990. Design of a membrane transport protein for fluorescence spectroscopy.  Proc. Natl. Acad. Sci. USA  87: 1638-1642.

Pourcher, T., Bassilana, M. Sarkar, H.K., Kaback, H.R., & Leblanc, G. 1990. The melibiose/Na+ symporter of Escherichia coli:  kinetic and molecular properties.  Phil. Trans. Royal Soc. Lond. B326:411-423.

Pourcher, T. Bassilana, M. Sarkar, H.K., Kaback, H.R., & Leblanc, G. 1990. Melibiose Permease and a-   Galactosidase of Escherichai coli:  Identification by Selective Labeling Using a T7 RNA Polymerase/Promoter Expression System.  Biochemistry 29:690-696.

Pourcher, T., Sarkar, H. K., Bassilana, M., Kaback, H. R. & LeBlanc, G. 1990. Histidine 94 is the Only Important Histidine Residue in the Melibiose Permease Activity of Escherichia coli. Proc. Natl. Acad. Sci. USA  87:468-472.

Roepe, P. D. & Kaback, H. R.  1990.  Isolation and functional reconstitution of soluble melibiose permease from Escherichia coli.  Biochemistry  29:2572-2577.

Roepe, P. D. & Kaback, H. R.  1989.  Characterization and functional reconstitution of a soluble form of the hydrophobic membrane protein lac permease from Escherichia coli .  Proc. Natl. Acad. Sci. USA  86:6087-6091.

Kaback, H. R.  1990.  Active transport:  Membrane vesicles, bioenergetics, molecules and mechanisms.  In:  The Bacteria, Vol XII  Chapter 6.   (Krulwich, T. A., ed.).  Academic Press, Orlando, FL, pp. 151-202.

Roepe, P. D., Zbar, R., Sarkar, H. K. & Kaback, H. R.  1989.  A five residue sequence near the carboxyl terminus of the polytopic membrane protein lac permease is required for stability within the membrane.  Proc. Natl. Acad. Sci. USA  86:3992-3996.

Roepe, P. D. & Kaback, H. R.  1989.  Site-Directed mutagenesis of tyrosine residues in the lac permease of Escherichia coli. Biochemistry  28:6127-6132.

Kaback, H. R.  1990.  Lac permease of Escherichia coli :  On the path of the proton.  Phil. Trans. Royal Soc. Lond. B326:425-436.

Kaback, H. R.  1989.  Use of site-directed mutagenesis to study the mechanism  of a membrane transportprotein.  In:  Perspectives in Biochemistry Vol. 1 (Neurath, H., ed.) American Chemical Society, Washington, D.C., pp. 224-229.

Kaback, H. R.  1989.  Molecular biology of active transport:  From membranes to molecules to mechanism.  The Harvey Lectures, Series  83:77-103.

Kaback, H. R.  1988.  Molecular mechanism of lactose/proton symport via the lac permease of Escherichia coli. In:  Molecular Basis of Biomembrane Transport, Vol 7 (Palmieri, F. & Quagiariello, E., eds.) Elsevier, The Netherlands, pp. 63-67.

Meinhart, S. W., Matsushita, K., Kaback, H. R. & Ohnishi, T.  1989.  EPR Characterization of the iron-sulfur containing NADH-ubiquinone oxireductase of the Escherichia coli aerobic respiratory chain.  Biochemistry 28:2153-2160.

Thorens, B., Sarkar, H. K., Kaback, H. R. & Lodish, H. F.  1988.  Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney and pancreatic islets.  Cell  55:281-290.

Lolkema, J., Püttner, I. B. & Kaback, H. R.  1988.  Site-directed mutagenesis of Pro327 in the lactose carrier of Escherichia coli .  Biochemistry  27:8307-8310.

Lee, J. A., Püttner, I. B. & Kaback, H. R.  1989.  Effect of distance and orientation between arginine-302, histidine-322 and glutamate-325 on the activity of lac permease from Escherichia coli .  Biochemistry 28:2540-2544.

Carrasco, N., Püttner, I. B., Antes, L. M., Lee, J. A., Larigan, J. D., Lolkema, J.S., Roepe, P.D. & Kaback, H. R. 1989.  Characterization of site-directed mutants in the lac permease of Escherichia coli:  II.  Glutamate-325  replacements.  Biochemistry  28:2533-2539.

Püttner, I. B., Sarkar, H. K., Padan, E., Lolkema, J. S. & Kaback, H. R.  1989. Characterization of site-directed mutants in the lac  permease of Escherichia coli:  I.  Replacement of histidine residues.  Biochemistry 28:2525-2533.

Sarkar, H. K., Thorens, B., Lodish, H. F. & Kaback, H. R.  1988.  Expression of  the human erythrocyte glucose transporter in Escherichia coli .  Proc. Natl.  Acad. Sci. USA  85:5463-5467.

Püttner, I. B. & Kaback, H. R.  1988.  Lac permease of Escherichia coli containing a single histidine residue is fully functional.  Proc. Natl. Acad. Sci. USA  85:1467-1471.

Lorence, R. M., Carter, K., Gennis, R. B., Matsushita, K. & Kaback, H. R.  1988.   Trypsin proteolysis of the cytochrome d complex of Escherichia coli  selectively inhibits ubiquinol oxidase activity while not affecting N,N,N',N'-tetramethyl-p-phenylendiamine oxidase activity.  J. Biol. Chem. 263:5271-5276.

Kaback, H. R.  1987.  Permease on parade:  Application of site-directed mutagenesis to ion-gradient driven active transport.  BioEssays  7:261-265.

Costello, M. J., Escaig, J., Matsushita, K., Viitanen, P. V., Menick, D. R. & Kaback, H. R.  1987.  Purified lac permease and cytochrome o oxidase are functional as monomers.  J. Biol. Chem. 262:17072-17082.

Matsushita, K., Ohnishi, T. & Kaback, H. R.  1987.  NADH-Ubiquinone oxidoreductase of the Escherichia coli aerobic respiratory chain.  Biochemistry 26:7732-7737.

Kaback, H. R.  1988.  Site-directed mutagenesis and ion-gradient driven active transport:  On the path of the proton.  Ann. Rev. Physiol. 50:243-256.

Menick, D. R., Carrasco, N., Antes, L., Patel, L. & Kaback, H. R.  1987.  Lac permease of Escherichia coli: Arginine-302 as a component of the postulated proton relay.  Biochemistry  26:6638-6644.

Kaback, H. R.  1987.  Use of site-directed mutagenesis to study the mechanism  of a membrane transport protein.  Biochemistry  26:2071-2076.

Menick, D. R., Lee, J. A., Brooker, R. J., Wilson, T. H. & Kaback, H. R.  1987.  The role of cysteine residues in the lac permease of Escherichia coli . Biochemistry  26: 1132-1136.

Carrasco, N., Antes, L. M., Poonian, M. S. & Kaback, H. R.  1986.  Lac permease of Escherichia coli :  His-322 and Glu-325 may be components of a charge-relay system.  Biochemistry  25:4486-4488.

Püttner, I. B., Sarkar, H. K., Poonian, M. S. & Kaback, H. R.  1986.  Lac permease of Escherichia coli :  His-205 and His-322 play different roles in  lactose/H+ symport.  Biochemistry  25:4483-4485.

Kaback, H. R., Carrasco, N., Lee, J. A., Menick, D. R., Patel, L., Püttner, I. B. &Sarkar, H. K.  1986.  Passage to Permease.  In:  Microbial Energy Transduction Chapter 24 (Cold Spring Harbor Laboratories, Cold Spring Harbor, NY) pp. 153- 156.

Matsushita, K. & Kaback, H. R.  1986.  D-Lactate oxidation and generation of the proton electrochemical gradient in membrane vesicles from Escherichia coli GR19N and in proteoliposomes reconstituted with purified D-lactate dehydrogenase and cytochrome o oxidase.  Biochemistry  25:2321-2327.

Katz, A., Avron, M. & Kaback, H. R.  1986.  Na+/H+ Antiport in isolated plasma membrane vesicles from Dunaliella salina.  FEBS Lett. 202:141-144.

Kaback, H. R.  1986.  The lac permease of Escherichia coli :  A jewel in the membrane.  In:  Ion Gradient-Coupled Transport  Alvarado, F. & Van Os, C.H., eds.  (Elsevier, Amsterdam) pp. 83-94.

Sarkar, H. K., Menick, D. R., Viitanen, P. V., Trumble, W. R., Poonian, M S. & Kaback, H. R.  1986.  Site-specific mutagenesis of cysteine-148 to serine of lac permease of Escherichia coli. J. Biol. Chem. 261:8914-8918.

Menick, D. R., Sarkar, H. K., Poonian, M. S. & Kaback, H. R.  1985.  Cys154 is important for lac permease activity in Escherichia coli .  Biochem. Biophys. Res. Commun. 132:162-170.

Sarkar, H. K., Viitanen, P. V., Poonian, M. S. & Kaback, H. R.  1986.  Substitution of glutamine-60 with glutamic acid causes the lac permease of  Escherichia coli  to become temperature sensitive.  Biochemistry  25:2778-2781.

Kaback, H. R.  1986.  Active transport in Escherichia coli :  Passage to permease.  Ann. Rev. Biophysics & Biophys. Chem. 15:279-319.

Moser, C. C., Matsushita, K., Robertson, D. E., Kaback, H. R. & Dutton, P. L. 1986.  Kinetics of electron transfer in reaction center-cytochrome o proteoliposomes.  FEBS Lett. 194:115-120.

Sung, S. J., Young, J. D., Origlio, A. M., Heiple, J. M., Kaback, H. R. & Silverstein, S. C.  1985.  Extracellular ATP perturbs transmembrane ion fluxes, elevates cytosolic [Ca++] and inhibits phagocytes in mouse macrophages.  J. Biol. Chem. 260:13442-13449.  

Danho, W., Makofske, R., Humiec, F., Gabriel, T. F., Carrasco, N. & Kaback, H. R.  1985.  Use of site-directed-polyclonal antibodies as immunotopological probes for the lac permease of Escherichia coli .  In:Peptides:  Structure & Function  Deber, C. M., Hruby, V. J. & Kopple, K. D., eds.  (Pierce Chem. Co.) pp. 59-62.

Viitanen, P. V., Menick, D. R., Sarkar, H. K., Trumble, W. R. & Kaback, H R. 1985.  Site-directed mutagenesis of cys148 in the lac permease of Escherichia coli :  Effect on transport, binding and sulfhydryl inactivation.  Biochemistry  24:7628-7635.

Padan, E., Sarkar, H. K., Viitanen, P. V., Poonian, M. S. & Kaback, H. R.  1985. Site-specific mutagenesis of histidine residues in the lac permease of  Escherichia coli .  Proc. Natl. Acad. Sci. USA  82:6765-6768.

Kaback, H. R.  1986.  Studies in a biological energy transducer:  The lac permease of Escherichia coli .  In:  New Insights into Cell and Membrane Transport Processes  Poste, G. & Crooke, S. T., eds.  (Plenum Publishing Co., New York, NY) pp. 23-38.

Sarkar, H. K., Viitanen, P. V., Padan, E., Trumble, W. R., Poonian, M. S., McComas, W. & Kaback, H. R.  1986. Oligonucleotide-directed site-specific mutagenesis of the lac permease of Escherichia coli .  Methods Enzymol. 125:214-230.

Matsushita, K., Patel, L. & Kaback, H. R.  1986.  Purification and reconstitution of the cytochrome o-type oxidase from Escherichia coli .  Methods Enzymol.   125:113-122.

Santos, E. & Kaback, H. R.  1986.  Monoclonal affinity purification of D-lactate dehydrogenase from Escherichia coli.  Methods Enzymol. 125:370-377.

Viitanen, P., Newman, M. J., Foster, D. L., Wilson, T. H. & Kaback, H. R.  1986. Purification, reconstitution and characterization of the lac permease of Escherichia coli. Methods Enzymol. 125:429-452.

Carrasco, N., Herzlinger, D. & Kaback, H. R.  1985.  An immunochemical approach to the study of membrane proteins.  I.  Monoclonal antibodies against the lac permease from Escherichia coli .  Methods Enzymol. 125:453-467.

Kaback, H. R.  1985.  Proton electrochemical gradients and active transport:  The saga of lac permease.  Ann. NY Acad. Sci. 456:291-304.

Carrasco, N., Herzlinger, D., DeChiara, S., Mitchell, R., Danho, W. & Kaback, H.R.  1985.  Topology of the lac carrier protein in the membrane of Escherichia coli.  Ann. NY Acad. Sci. 456:305-306.

Viitanen, P. V., Sarkar, H. K., Menick, D., Trumble, W. R., Padan, E., McComas, W., Poonian, M. & Kaback, H. R.  1985.  Site-Directed mutagenesis of the lacY gene of Escherichia coli .  Ann. NY Acad. Sci. 456:307-308.

Santos, E., Tahara, S. M. & Kaback, H. R.  1985.  Monoclonal antibodies against the membrane-bound, flavin-linked D-lactate dehydrogenase of Escherichia coli : Preparation, characterization, and use in immunoaffinity chromotography. Biochemistry  24:3006-3011.

Herzlinger, D., Carrasco, N. & Kaback, H. R.  1985.  Functional and immunochemical characterization of a mutant of Escherichia coli  energy-coupled for lactose transport.  Biochemistry  24:221-229.

Hamamoto, T., Carrasco, N., Matsushita, K., Kaback, H. R. & Montal, M.  1985. Direct measurement of the electrogenic activity of o-type cytochrome oxidase from Escherichia coli  reconstituted into planar lipid bilayers.  Proc. Natl. Acad. Sci. USA  82:2570-2573.

Hiller, R., Schaefer, A., Zibirre, R., Kaback, H. R. & Koch, G.  1984.  Factors influencing the accumulation of tetraphenylphosphonium cation in HeLa cells. Mol. & Cell. Biol. 4:199-202.

Costello, M. J., Viitanen, P., Carrasco, N., Foster, D. L. & Kaback, H. R.  1984. Morphology of proteoliposomes reconstituted with purified lac carrier protein from Escherichia coli .  J. Biol. Chem. 259:15579-15586.

Matsushita, K., Patel, L. & Kaback, H. R.  1984.  Cytochrome o oxidase from Escherichia coli .  Characterization of the enzyme and mechanism of electrochemical proton gradient generation.  Biochemistry  23:4703-4714.

Kaback, H. R.  1985.  From membrane to molecule with the lac permease of Escherichia coli .  In:  Current Topics in Cellular Regulation Ginsberg, & Levine, R. L., eds.  (Academic Press, New York, NY) pp. 137-148.

Carrasco, N., Herzlinger, D., Mitchell, R., DeChiara, S., Danho, W., Gabriel, T. F. & Kaback, H. R.  1984.  Intramolecular dislocation of the C-terminus of the lac carrier protein in reconstituted proteoliposomes.  Proc. Natl. Acad. Sci. USA 81:4672-4676.

Herzlinger, D., Viitanen, P., Carrasco, N. & Kaback, H. R.  1984.  Monoclonal antibodies against the lac carrier protein from Escherichia coli .  II.  Binding studies with membrane vesicles and proteoliposomes reconstituted with purified lac carrier protein.  Biochemistry  23:3688-3693.

Carrasco, N., Viitanen, P., Herzlinger, D. & Kaback, H. R.  1984.  Monoclonal antibodies against the lac carrier protein from Escherichia coli .  I.  Functional  studies.  Biochemistry  23:3681-3687.

Trumble, W. R., Viitanen, P. V., Sarkar, H. K., Poonian, M. S. & Kaback, H. R. 1984.  Site-directed mutagenesis of Cys148 in the lac carrier protein of   Escherichia coli .  Biochem. Biophys. Res. Commun. 119:860-867.

Goldkorn, T., Rimon, G., Kempner, E. S. & Kaback, H. R.  1984.  Functional  molecular weight of the lac carrier protein from Escherichia coli  as studied by radiation inactivation analysis.  Proc. Natl. Acad. Sci. USA  81:1021-1025.

Viitanen, P., Garcia, M. L. & Kaback, H. R.  1984.  Purified, reconstituted lac carrier protein from Escherichia coli  is fully functional.  Proc. Natl. Acad. Sci. USA  81: 1629-1633.

Kaback, H. R.  1986.  Active transport in Escherichia coli :  From membrane to molecule.  In:  Physiology of Membrane Disorders Andreoli, T. E., Hoffman, J. F., Fanestil, D. D. & Schultz, S. G., eds.  (Plenum Press, New York, NY) pp. 387- 408.

Kaback, H. R.  1983.  The lac carrier protein in Escherichia coli :  From membrane to molecule.  J. Membr. Biol. 76:95-112.

Matsushita, K., Patel, L., Gennis, R. B. & Kaback, H. R.  1983.  Reconstitution of active transport in                       proteoliposomes containing cytochrome o oxidase and lac carrier protein purified from Escherichia coli .  Proc. Natl. Acad. Sci. USA 80:4889-4893.

Goldkorn, T., Rimon, G. & Kaback, H. R.  1983.  Topology of the lac carrier protein in the membrane of Escherichia coli .  Proc. Natl. Acad. Sci. USA  80:3322-3326.

Viitanen, P., Garcia, M. L., Foster, D. L., Kaczorowski, G. J. & Kaback, H. R. 1983.  Mechanism of lactose translocation in proteoliposomes reconstituted with lac carrier protein purified from Escherichia coli .  2. Deuterium solvent isotope effects.  Biochemistry  22:2531-2536.

Garcia, M. L., Viitanen, P., Foster, D. L. & Kaback, H. R.  1983.  Mechanism of lactose translocation in imposed membrane potential on efflux, exchange and counterflow.  Biochemistry  22:2524-2531.

Mates, S. M., Patel, L., Kaback, H. R. & Miller, M. H.  1983.  Membrane potential and its relationship to gentamicin uptake in anaerobically growing Staphylococcus aureus.  Antimicrob. Agts. Chemother 23:526-530.

Young, J. D., Unkeless, J. C., Kaback, H. R. & Cohn, Z. A.  1983.  Mouse macrophage Fc receptor for IgGg2B/g1 in artificial and plasma membrane vesicles functions as a ligand-dependent ionophore.  Proc. Natl. Acad. Sci.  USA  80:1636-1640.

Young, J. D., Unkeless, J. C., Kaback, H. R. & Cohn, Z. A.  1983.  Macrophage membrane potential changes associated with g2b/g1 Fc receptor-ligand binding.  Proc. Natl. Acad. Sci. USA  80:1357-1361.

Kaback, H. R., Carrasco, N., Foster, D., Garcia, M. L., Goldkorn, T., Patel, L.and Viitanen, P.  1984.  The lac carrier protein from Escherichia coli .  In: Electrogenic Transport.  Fundamental Principles and Physiological  Implications  Blaustein, M. & Lieberman, M., eds.  (Raven Press, New York) pp.323-330.

Foster, D. L., Boublik, M. & Kaback, H. R.  1983.  Structure of the lac carrier protein of Escherichia coli .  J. Biol. Chem. 258:31-34.

Carrasco, N., Tahara, S. M., Patel, L., Goldkorn, T. & Kaback, H. R.  1982.  Preparation, characterization and properties of monoclonal antibodies against the lac carrier protein from Escherichia coli .  Proc. Natl. Acad. Sci. USA  79:6894- 6898.

Mates, S., Eisenberg, E. S., Mandel, L. J., Patel, L., Kaback, H. R. & Miller, M.H. 1982. Membrane potential and gentamicin uptake in Staphylococcus aureus. Proc. Natl. Acad. Sci. USA  79:6693-6697.

Patel, L., Garcia, M.-L. & Kaback, H. R.  1982.  Direct measurement of lactose/proton symport in Escherichia coli  membrane vesicles:  Further evidence for the involvement of a histidine residue(s).  Biochemistry 21:5805- 5810.

Garcia, M.-L., Patel, L., Padan, E. & Kaback, H. R.  1982.  Mechanism of lactose transport in Escherichia coli  membrane vesicles:  Evidence for the involvement  of a histidine residue(s) in the response of the lac carrier to the proton electrochemical gradient.  Biochemistry  21:5800-5805.

Foster, D. L., Garcia, M. L., Newman, M. J., Patel, L. & Kaback, H. R.  1982.  Lactose:  Proton symport by purified lac carrier protein.  Biochemistry  21:5634-5638.

Santos, E., Kung, H.-F., Young, I. G. & Kaback, H. R.  1982.  In vitro synthesisof the membrane-bound D-lactate dehydrogenase of Escherichia coli .  Biochemistry  21: 2085-2091.

Gruner, S. M., Kirk, G., Patel, L. & Kaback, H. R.  1982.  A method for rapid, continuous monitoring of solute uptake and binding.  Biochemistry  21:3239-3243.

Haldar, K., Olsiewski, P. J., Walsh, C., Kaczorowski, G. J., Bhaduri, A. & Kaback, H. R.  1982.  Simultaneous reconstitution of Escherichia coli  membrane vesicles with D-lactate and D-amino acid dehydrogenases.  Biochemistry  21:4590-4596.

Newman, M. J., Foster, D., Wilson, T. H. & Kaback, H. R.  1981.  Purification  and reconstitution of functional lactose carrier from Escherichia coli .  J. Biol. Chem. 256: 11804-11808.

Olsiewski, P., Kaczorowski, G., Walsh, C. T. & Kaback, H. R.  1981.  Reconstitution of Escherichia coli  membrane vesicles with D-amino acid dehydrogenase.  Biochemistry  21:6272-6279.

Santos, E. & Kaback, H. R.  1981.  Involvement of the proton electrochemical  gradient in genetic transformation in Escherichia coli .  Biochem. Biophys. Res. Commun. 99:1153-1160.

Hugenholtz, J., Hong, J.-S. & Kaback, H. R.  1981.  ATP-Driven active transport in right-side-out bacterial membrane vesicles.  Proc. Natl. Acad. Sci. USA 78:3446-3449.

Kaback, H. R.  1982.  Mechanisms of active transport in isolated bacterial membrane vesicles.  In:  Membranes and Transport:  A Critical Review Vol. 2 Martonosi, A. N., ed.  (Plenum Press, New York, NY) pp. 21-25.

Kaback, H. R.  1981.  Mechanism of H+/lactose symport in Escherichia coli .  In: Chemiosmotic Proton Cricuits in Biological Membranes  Skulachev, V. P. & Hinkle, P. C., eds.  (Addison-Wesley Publishing Co., Reading, MA) pp. 525-536.

Guffanti, A. A., Cohn, D. E., Kaback, H. R. & Krulwich, T. A.  198. Relationship between the Na+/H+ antiporter and the Na+/substrate symport in Bacillus alcalophilus.  Proc. Natl. Acad. Sci. USA  78:1481-1484.

Cohn, D., Kaczorowski, G. J. & Kaback, H. R.  1981.  Effect of the proton electrochemical gradient on maleimide inactivation of active transport in Escherichia coli  membrane vesicles.  Biochemistry  20:3308-3313.

Kaczorowski, G. J., Robertson, D. E., Garcia, M. L., Padan, E., Patel, L., LeBlanc, G. & Kaback, H. R.  1980.  Energetics and mechanism of lactose translocation in isolated membrane vesicles of Escherichia coli.  Ann. NY Acad. Sci. 358:307-321.

Owen, P., Kaback, H. R. & Graeme-Cook, K. A.  1980.  Identification of antigen 19/27 as dihydrolipoyl dehydrogenase and its probable involvement in ubiquinone-mediated NADH-dependent transport phenomena in membrane  vesicles of Escherichia coli.  FEMS Microbiol. Lett. 7:345-348.

Kaczorowski, G. J., Robertson, D. E. & Kaback, H. R.  1980.  Mechanism of lactose translocation in membrane vesicles from Escherichia coli.  Ann. NY Acad. Sci. 341: 473-481.

Kaczorowski, G. J., LeBlanc, G. & Kaback, H. R.  1980.  Specific labeling of the lac carrier protein in membrane vesicles of Escherichia coli  by a novel photoaffinity reagent.  Proc. Natl. Acad. Sci. USA  77:6319-6323.

obertson, D. E., Kaczorowski, G. J., Garcia, M.-L. & Kaback, H. R.  1980.  Active transport in membranevesicles from Escherichia coli :  The electrochemical proton gradient alters the distribution of the lac carrier between two different kinetic states.  Biochemistry  19:5692-5702.

Cohn, D. E. & Kaback, H. R.  1980.  Mechanism of the melibiose porter in membrane vesicles of Escherichia coli. Biochemistry  19:4237-4243.

Kaback, H. R.  1982.  In:  Current Topics in Membranes and Transport Vol. 16.  Bronner, F. & Kleinzeller, A., eds. (Academic Press, New York, NY) pp. 393-404.

Felle, H., Porter, J. J., Slayman, C. L. & Kaback, H. R.  1980.  Quantitative measurements of membrane potential in Escherichia coli .  Biochemistry 19:3585-3590.

LeBlanc, G., Rimon, G. & Kaback, H. R.  1980.  Glucose-6-P transport in membrane vesicles isolated from Escherichia coli: Effect of imposed Dmand ‚ ?pH..  Biochemistry  19:2522-2528.

Kiefer, H., Blume, A. J. & Kaback, H. R.  1980.  Membrane potential changes during mitogenic stimulation of mouse spleen lymphocytes.  Proc. Natl. Acad. Sci. USA  77: 2200-2204.

Owen, P., Kaczorowski, G. J. & Kaback, H. R.  1980.  Resolution and identification of iron-containing antigens in membrane vesicles from Escherichia coli .  Biochemistry  19:596-600.

Padan, E., Patel, L. & Kaback, H. R.  1979.  Effect of diethylpyrocarbonate on lactose/proton symport in Escherichia coli  membrane vesicles.  Proc. Natl. Acad. Sci. USA  76:6221-6225.

Padan, E., Schuldiner, S. & Kaback, H. R.  1979.  Reconstitution of lac carrier function in cholate-extracted membranes from Escherichia coli .  Biochem. Biophys. Res. Commun. 91:854-861.

Reenstra, W. W., Patel, L, Rottenberg, H. & Kaback, H. R.  1980.  The electrochemical proton gradient in inverted membrane vesicles from Escherichia coli .  Biochemistry   19:1-9.

Friedberg, I. & Kaback, H. R.  1980.  The electrochemical proton gradient in Micrococcus lysodeikticus  cells and membrane vesicles.  J. Bacteriol. 142:651- 658.

Kaback, H. R.  1979.  Electrochemical ion gradients and active transport.  In: Function and Molecular Aspects of Biomembrane Transport Quagliariello, E., eds.  (Elsevier/North-Holland Biomedical Press) pp. 229-238.

Kaback, H. R.  1980.  Electrochemical ion gradients and active transport.  Ann. NY Acad. Sci. 339:53-60.

Kaczorowski, G. J., Robertson, D. E. & Kaback, H. R.  1979.  Mechanisms of lactose translocation in membrane vesicles from Escherichia coli .  II.  Effect of imposed Dm, ‚ Dm, ?pH and Dm+?pH. Biochemistry  18:3697-3704.

Kaczorowski, G. J. & Kaback, H. R.  1979.  Mechanisms of lactose translocation in membrane vesicles from Escherichia coli .  I.  Effect of pH on efflux, exchange and counterflow.  Biochemistry  18:3691-3697.

Grollman, E., Lee, G., Ramos, S., Lazo, P. S., Kaback, H. R., Friedman, R. M. & Kohn, L. D.  1978.  Relationships  of the structure and function of the interferon receptor to hormone receptors and establishment of the antiviral state.  Cancer Res. 38:4172-4185.

Owen, P. & Kaback, H. R.  1979.  Antigenic architecture of membrane vesicles from Escherichia coli .   Biochemistry  18:1422-1426.

Owen, P. & Kaback, H. R.  1979.  Immunochemical analysis of membrane vesicles from Escherichia coli.                      Biochemistry  18:1413-1422.

Ramos, S., Grollman, E. F., Lazo, P. S., Dyer, S. A., Habig, W. H., Hardegree, M.C., Kaback, H. R. & Kohn, L. D. 1979.  Effect of tetanus toxin on the accumulation of the permeant lipophilic cation tetraphenylphosphonium by guinea pig brain synaptosomes.  Proc. Natl. Acad. Sci. USA  76:4783-4787.

Lichtshtein, D., Dunlop, K., Kaback, H. R. & Blume, A. J.  1979.  Mechanism of monensin-induced hyperpolarization of neuroblastoma x glioma hybrid cells NG108-15.  Proc. Natl. Acad. Sci. USA  76:2580-2584.

Stroobant, P. & Kaback, H. R.  1979.  Reconstitution of ubiquinone-linked functions in membrane vesicles from a double quinone mutant of Escherichia coli.  Biochemistry  18:226-231.

Lichtshtein, D., Kaback, H. R. & Blume, A. J.  1979.  Use of a lipophilic cationfor determination of membrane potential in neuroblastoma x glioma hybrid cell suspensions.  Proc. Natl. Acad. Sci. USA  76:650-654.

Owen, P. & Kaback, H. R.  1978.  Molecular structure of membrane vesicles from Escherichia coli .  Proc. Natl. Acad. Sci. USA 75:3148-3152.

Kaback, H. R., Kaczorowski, G. J., Patel, L. & Robertson, D. E.  1978. Molecular biology and energetics of active transport.  In:  Frontiers in Biological Energetics:  Electrons to Tissues  Dutton, P. L., Leigh, J. S. & Scarpa, A., eds. (Academic Press, New York, NY, Vol. II) pp. 1119-1127.

Kaback, H. R. & Patel, L.  1978.  The role of functional sulfhydryl groups in active transport in Escherichia coli membrane vesicles.  Biochemistry  17:1640- 1646.

Kaczorowski, G., Kohn, L. & Kaback, H. R.  1978.  Purification and properties of D-lactate dehydrogenase from Escherichia coli  ML 308-225.  In:  Methods in Enzymology.  Fleischer, S. & Packer, L., eds., Vol. LIII  (Academic Press, New York, NY) pp. 519-527.

Kaback, H. R.  1978.  Energetics of active transport in isolated bacterial membrane vesicles.  In:  The Proton and Calcium Pumps  Azzone, G. F et al., eds.  (Elsevier/North-Holland Biomedical Press) pp. 115-123.

Tokuda, H. & Kaback, H. R.  1978.  Sodium-dependent binding of p-nitrophenyl-a-D-galactopyranoside to membrane vesicles isolated from Salmonella typhimurium.  Biochemistry  17:698-705.

Kaback, H. R., Ramos, S., Robertson, D. E., Stroobant, P. & Tokuda, H.  1977. Energetics and molecular biology of active transport in bacterial membrane vesicles.  In:  Molecular Aspects of Membrane Transport Oxender, D.L. & Fox, C. F., eds.  (Alan R. Liss, Inc., Vol. 2) pp. 473-491.

Ramos, S., Schuldiner, S. & Kaback, H. R.  1977.  Use of flow dialysis for determinations of ‚ ?pH and active transport.  In:  Methods in Enzymology Vol. Fleischer, S. & Packer, L., eds.  (Academic Press, New York, NY) pp. 680-688.

Ramos, S. & Kaback, H. R.  1977.  pH-Dependent changes in proton:substrate stoichiometries during active  transport in Escherichia coli membrane vesicles.  Biochemistry  16:4271-4275.

Grollman, E. F., Lee, G., Ambesi-Impiombato, F. S., Meldolesi, M. F., Aloj, S. M., Coon, H. G., Kaback, H. R. & Kohn, L. D.  1977.  Effects of thyrotropin on the thyroid cell membrane:  Hyperpolarization induced by hormone-receptor Interaction.  Proc. Natl. Acad. Sci. USA  74:2352-2356.

Schuldiner, S. & Kaback, H. R.  1977.  Fluorescent galactosides as probes for the lac carrier protein.  Biochim. Biophys. Acta  472:399-418.

Schuldiner, S., Weil, R., Robertson, D. E. & Kaback, H. R.  1977.  The microenvironment of the binding site in the lac carrier protein.  Proc. Natl. Acad. Sci. USA  74:1851-1855.

Tokuda, H. & Kaback, H. R.  1977.  Sodium-dependent methyl 1-thio-b-D-galactopyranoside transport in membrane vesicles isolated from Salmonella typhimurium.  Biochemistry  16:2130-2136.

George-Nascimento, C., Wakil, S. J., Short, S. A. & Kaback, H. R.  1976.  Effects of lipids on the reconstitution of D-lactate oxidase in Escherichia coli  membrane  vesicles.  J. Biol. Chem. 251:6662-6666.

Kaback, H. R., Ramos, S., Robertson, D. E., Stroobant, P. & Tokuda, H.  1978. In:  Molecular Specialization and Symmetry in Membrane Function  Solomon, A. K. & Karnovsky, M., eds.  (Harvard University Press, Cambridge, MA and London) pp. 160-188.

Kaback, H. R.  1976.  Molecular biology and energetics of membrane transport. J. Cell. Physiol. 89:575-594.

Kaback, H. R.  1977.  In:  Biochemistry of Membrane Transport (Proc. FEBS Symp. No. 42) Semenza, G. & Carafoli, E., eds., pp. 598-625.

Ramos, S. & Kaback, H. R.  1977.  The relationship between the electrochemical proton gradient and active transport in Escherichia coli  membrane vesicles. Biochemistry  16:854-859.

Ramos, S. & Kaback, H. R.  1977.  The electrochemical proton gradient in Escherichia coli  membrane vesicles. Biochemistry  16:848-854.

Rudnick, G., Schuldiner, S. & Kaback, H. R.  1976. Equilibrium between two forms of the lac carrier protein in energized and nonenergized membrane vesicles from Escherichia coli .  Biochemistry  15:5126-5131.

Schuldiner, S., Rudnick, G. Weil, R. & Kaback, H. R.  1976.  Mechanism of b-galactoside transport in Escherichia coli  membrane vesicles.  TIBS pp. 41-45.

Ramos, S. & Kaback, H. R.  1976.  The Electrochemical Proton Gradient in Escherichia coli  Membrane Vesicles and its Relationship to Active Transport. Abstracts of Communication (Cambridge) 5:23-25.

Ramos, S., Schuldiner, S. & Kaback, H. R.  1976.  The electrochemical gradient of protons and its relationship to active transport in Escherichia coli  membrane vesicles.  Proc. Natl. Acad. Sci. USA 73:1892-1896.

Patel, L. & Kaback, H. R.  1976.  The role of the carbodiimide-reactive component of the adenosine- 5'-triphosphatase complex in the proton permeability of Escherichia coli  membrane vesicles.  Biochemistry 15:2741-2746.

Boonstra, J., Gutnick, D. & Kaback, H. R.  1975.  Physiological suppression of a transport defect in mutants of Escherichia coli  deficient in Ca++, Mg++-  stimulated adenosine triphosphatase.  J. Bacteriol. 124:1248-1255.

Kaczorowski, G., Kaback, H. R. & Walsh, C.  1975.  Reversible inactivation of  vectorial phosphorylation by hydroxybutynoate in Escherichia coli  membrane vesicles.  Biochemistry   14:3903-3908.

Stroobant, P. & Kaback, H. R.  1975.  Ubiquinone-mediated coupling of NADH dehydrogenase to active transport in membrane vesicles from Escherichia coli .  Proc. Natl. Acad. Sci. USA   72:3970-3974.  This is paper XXXII in a series.

Kaback, H. R., Rudnick, G. & Schuldiner, S. & S. A. Short  1975.  Active             transport in isolated bacterial membrane vesicles:  Binding of b-galactosides to             the lac carrier protein.  Ann. NY Acad. Sci. 264:350-357.

Kahane, S., Marcus, M., Barash, H., Halpern, Y. S. & Kaback, H. R.  1975. Sodium dependent glutamate transport in membrane vesicles of Escherichia coli K-12.  FEBS Lett. 56:235-239.

Boonstra, J., Huttunen, M. T., Konings, W. N. & Kaback, H. R.  1975.  Anaerobic transport in Escherichia coli membrane vesicles.  J. Biol. Chem. 250:6792-6798.

Schuldiner, S., Weil, R. & Kaback, H. R.  1976.  Energy dependent binding of dansylgalactoside to the lac carrier protein:  Direct binding measurements.  Proc. Natl. Acad. Sci. USA  73:109-112.  This is paper XXXI in a series.

Schuldiner, S., Spencer, R. D., Weber, G., Weil, R. & Kaback, H. R.  1975.  Lifetime and rotational relaxation times of dansylgalactosides bound to the b- galactoside carrier protein.  J. Biol. Chem. 250:8893-8896.  This is paper  XXX in a series.

Patel, L., Schuldiner, S. & Kaback, H. R.  1975.  Reversible effects of chaotropic agents on the proton permeability of Escherichia coli  membrane vesicles.  Proc. Natl. Acad. Sci. USA  72:3387-3391.  This is paper XXIX in a series.

Schuldiner, S. & Kaback, H. R.  1975.  Membrane potentials and active transport in membrane vesicles from Escherichia coli .  Biochemistry   14:5451-5461.  This is paper XXVIII in a series.

Rudnick, G., Weil, R. & Kaback, H. R.  1975.  Photoinactivation of the b-galactoside transport system in Escherichia coli  membrane vesicles with 2'-N(2-nitro-4-azidophenyl)aminoethyl-1-thio-b-D-galactopyranoside.  J. Biol. Chem. 250:6847-6851.  This is paper XXVII in a series.

Kaback, H. R., Rudnick, G., Schuldiner, S., Short, S. A. & Stroobant, P.  1976. Molecular aspects of active transport.  In:  The Structural Basis of Membrane Function  Hatefi, Y. & Djavadi-Ohaniance, L, eds.  (Academic Press, New York, NY) pp. 107-128.

Schuldiner, S., Kung, H., Weil, R. & Kaback, H. R.  1975.  Differentiationbetween binding and transport of dansylgalactosides in Escherichia coli .  J. Biol. Chem. 250: 3679-3682.  This is paper XXVI in a series.

Kaback, H. R., Rudnick, G., Schuldiner, S. & Short, S. A.  1975.  Isolated bacterial cytoplasmic membrane vesicles:  A model system for the study of active transport.  In:  Molecular Aspects of Membrane Phenomena Kaback, H. R., Neurath, H., Radda, G. K., Schwyzer, R. & Wiley, W. R., eds.  (Springer-Verlag, Germany/New York) pp. 249-265.

Shaw, L., Grau, F., Kaback, H. R., Hong, J.-S. & Walsh, C.  1975.  Vinylglycolate resistance in Escherichia coli .  J. Bacteriol. 121:1047-1055.

Short, S. A., Kaback, H. R. & Kohn, L. D.  1975.  Localization of D-lactate dehydrogenase in native and reconstituted Escherichia coli  membrane vesicles. J. Biol. Chem. 250:4291-4296.

Short, S. A., Hawkins, T., Kohn, L. D. & Kaback, H. R.  1974.  Immunochemical properties of the membrane-bound D-lactate dehydrogenase from Escherichia coli.  J. Biol. Chem. 250:4285-4290.  This is paper XXIV in a series.

Cox, G. S., Weissbach, H. & Kaback, H. R.  1975.  Transport in an Escherichia coli  fatty acid auxotroph.  A novel case of catabolite repression.  J. Biol. Chem. 250: 4542-4548.

Short, S. A., Kaback, H. R., Kaczorowski, G., Fisher, J. Walsh, C. T. & Silverstein, S.  1974.  Determination of the absolute number of Escherichia coli membrane vesicles which catalyze active transport.  Proc. Natl. Acad. Sci.  USA 71: 5032-5036.  This is paper XXIII in a series.

Boublik, M., Jenkins, F. & Kaback, H. R.  1975.  Use of critical point drying in the preparation of Escherichia coli membrane vesicles for electron microscopy. Cytobiologie  11:304-308.

Kaback, H. R., Lombardi, F. J., Rudnick, G., Schuldiner, S. & Short, S. A.  1974.  Transport in isolated bacterial membrane vesicles.  First International Congress of  the International Association of Microbiological Societies, Tokyo, Japan, September, 1974.

Rudnick, G., Weil, R. & Kaback, H. R.  1975.  Photoinactivation of the beta-galactoside transport system in Escherichia coli  membrane vesicles with 2-nitro-4-azidophenyl-1-thio-b-D-galactopyranoside.  J. Biol. Chem. 250:1371-1375.  This is paper XXII in a series.

Schuldiner, S., Kerwar, G. K., Weil, R. & Kaback, H. R.  1975.  Energy-dependent binding of dansylgalactosides to the b-galactoside carrier protein.  J. Biol. Chem. 250: 1361-1370.  Paper XXI in a series.

Kaback, H. R.  1974.  Transport studies in bacterial membrane vesicles.  Science 186:882-892.

Lombardi, F. J., Reeves, J. P., Short, S. A. & Kaback, H. R.  1974.  Evaluation of the chemiosmotic interpretation of active transport in bacterial membrane vesicles.  Annals NY Acad. Sci. 227:312-327.

Kaback, H. R.  1974.  Active transport in isolated bacterial membrane vesicles.  In:  Perspectives in Membrane Biology Estrado-O, S. & Gitler, C., eds.(Academic Press, New York, NY) pp. 213-227.

Short, S. A., Kaback, H. R. & Kohn, L. D.  1974.  D-Lactate dehydrogenase binding in Escherichia coli  dld- membrane vesicles reconstituted for active transport.  Proc. Natl. Acad. Sci. USA  71:1461-1465.

Short, S. A. & Kaback, H. R.  1974.  Mechanisms of active transport in isolated bacterial membrane vesicles. Further studies on amino acid transport in Staphylococcus aureus membrane vesicles.  J. Biol. Chem. 249:4275-4281.

Reeves, J. P. & Kaback, H. R.  1974.  The mechanism of active transport inbacterial membrane vesicles.  PAABS Revista  3:209-219.

Cox, G. S., Kaback, H. R. & Weissbach, H.  1974.  Defective transport in S-adenosylmethionine synthetase mutants of Escherichia coli .  Arch. Biochem. Biophys. 161:610-620.

Kaback, H. R., Reeves, J. P., Short, S. A. & Lombardi, F. J.  1974.  Mechanisms of active transport in isolated bacterial membrane vesicles.  XVIII.  The mechanism of action of carbonyl cyanide m-chlorophenylhydrazone. Arch. Biochem. Biophys. 160: 215-222.

Konings, W. N. & Kaback, H. R.  1973.  Anaerobic transport in Escherichia coli membrane vesicles.  Proc. Natl. Acad. Sci. USA  70:3376-3381.  This is paper XVII in a series.

Reeves, J. P., Shechter, E., Weil, R. & Kaback, H. R.  1973.  Dansylgalactoside, a fluorescent probe of active transport in bacterial membrane vesicles.  Proc. Natl. Acad. Sci. USA   70:2722-2726.

Kaback, H. R.  1973.  Bacterial transport mechanisms.  Proc. of the Australian Biochem. Soc. 6: 1.

Short, S. A. & Kaback, H. R.  1974.  Amino acid transport and Staphylococcus membrane vesicles.  Ann. NY Acad. Sci. 236:124.

Walsh, C. T. & Kaback, H. R.  1974.  Membrane transport as a potential target for antibiotic action.  Ann. NY Acad. Sci. 235:519-541.

Cox, G. S., Thomas, E., Kaback, H. R. & Weissbach, H.  1973.  Synthesis of cyclopropane fatty acids in isolated bacterial membranes.  Arch. Biochem. Biophys. 158:667-676.

Kohn, L. D. & Kaback, H. R.  1973.  Mechanisms of active transport in isolated bacterial membrane vesicles. XV.  Purification and properties of the membrane- bound D-lactate dehydrogenase from Escherichia coli .  J. Biol. Chem. 248:7012- 7017.

Reeves, J. P., Hong, J.-s. & Kaback, H. R.  1973.  Reconstitution of D-lactate dependent transport in membrane vesicles from a D-lactate dehydrogenase mutant of Escherichia coli.  Proc. Natl. Acad. Sci. USA  70:1917-1921.

Kaback, H. R.  1974.  Transport in isolated bacterial membrane vesicles.  In: Methods Enzymol. Vol. XXXI. Fleischer, S. & Packer, L., eds.  (Academic Press, New York, NY)  pp. 698-709.

Walsh, C. T. & Kaback, H. R.  1973.  Vinylglycolic acid:  An inactivator of the P-enolpyruvate-P-transferase system in Escherichia coli .  J. Biol. Chem. 248:5456- 5462.

Lombardi, F. J., Reeves, J. P. & Kaback, H. R.  1973.  Mechanisms of active transport in isolated bacterial membrane vesicles.  XIII.  Valinomycin-induced rubidium transport.  J. Biol. Chem. 248:3551-3565.

Thomas, Edwin L., Weissbach, H. & Kaback, H. R.  1973.  Studies on the metabolism of ATP by isolated bacterial membranes:  Solubilization and phosphorylation of a protein component of the diglyceride kinase system. Arch. Biochem. Biophys. 157: 327-333.

Kaback, H. R.  1973.  Bacterial transport mechanisms.  In:  Bacterial Membrane and Walls Vol. I, Leive, L., ed. (Marcel Dekker, New York)  pp. 241-292.

Kaback, H. R.  1973.  Active transport in bacterial cytoplasmic membrane vesicles, Symposia of the Society for Experimental Biology XXVII, Davies, D. D., ed.  (Cambridge University Press, England)  p. 145.

Kaback, H. R. & Hong, J.-S.  1973.  Membranes and transport.  In:  CRC Critical Reviews in Microbiology Vol. 2, Laskin, A. I. & Lechevalier, H., eds.  (CRC Press, Ohio) pp. 333-376.

Kaback, H. R.  1972.  Discussion paper: bacterial transport mechanisms as studied in cytoplasmic membrane vesicles.  Ann. NY Acad. Sci. 195:407-411.

Prezioso, G., Hong, J.-S., Kerwar, G. K. & Kaback, H. R.  1973.  Mechanisms of active transport in isolated membrane vesicles.  XII.  Active transport in mutant of Escherichia coli  uncoupled for oxidative phosphorylation.  Arch. Biochem. Biophys. 154:575-582.

Hong, J.-S. & Kaback, H. R.  1972.  Mutants of Salmonella typhimurium and Escherichia coli  pleiotropically defective in active transport.  Proc. Natl. Acad.Sci. USA  69:3336-3340  (This paper is No. XI in a series).

Walsh, C. T., Abeles, R. H. & Kaback, H. R.  1972.  Mechanisms of active transport in isolated bacterial membrane vesicles.  X.  Inactivation of D-lactate dehydrogenase and D-lactate dehydrogenase-coupled  transport in Escherichia coli  membrane vesicles by an acetylenic substrate.  J. Biol. Chem. 247:7858-7863.

Short, S. A., White, D. C. & Kaback, H. R.  1972.  Mechanisms of active transport in isolated bacterial membrane vesicles.  IX.  The kinetics and  specificity of amino acid transport in Staphylococcus aureus membrane   vesicles.  J. Biol. Chem. 247:7452-7458.

Kaback, H. R., Barnes, E. M., Jr., Gordon, A. S., Lombardi, F. J. & Kerwar, G. K. 1972.  Sugar and amino acid transport mechanisms in isolated bacterial membrane  vesicles.  In:  Molecular Basis of Biological Activity  Gaede, K., Horecker, B. L. & Whelan, W. J., eds.  (Academic Press, New York, NY) p. 373.

Lombardi, F. J. & Kaback, H. R.  1972.  Mechanisms of active transport in isolated bacterial membrane vesicles.  VIII.  The transport of amino acids by membranes prepared from Escherichia coli .  J. Biol. Chem. 247:7844-7857.

Reeves, J. P., Lombardi, F. J. & Kaback, H. R.  1972.  Mechanisms of active transport in isolated bacterial membrane vesicles.  VII.  Fluorescence of 1-analino-8-naphthalenesulfonate during D-lactate oxidation by membrane vesicles from Escherichia coli .  J. Biol. Chem. 247:6204-6211.

Thomas, Edwin L., Weissbach, H. & Kaback, H. R.  1972.  Further studies on metabolism of phosphatidic acid of isolated Escherichia coli  membrane vesicles. Arch. Biochem. Biophys. 150:797.

Kaback, H. R.  1972.  Transport mechanisms in isolated bacterial cytoplasmic membrane vesicles.  In: Membrane Research Fox, Fred C., ed.  (Academic Press, New York, NY) p. 473-501.

Kaback, H. R.  1972.  Transport mechanisms in isolated bacterial cytoplasmic membrane vesicles.  In:  The Molecular Basis of Biological Transport Woessner, J. F., Jr. & Huijing, F., eds.  (Academic Press, New York, NY) pp. 291-328.

Kaback, H. R.  1972.  Transport across isolated bacterial cytoplasmic membranes. Biochim. Biophys. Acta 265:367-416.

Shechter, E., Gulik-Krzywicki & Kaback, H. R.  1972.  Correlation between structural and physiological properties in isolated cytoplasmic membrane vesicles from Escherichia coli --X-ray diffraction, fluorescence and transport studies.  Biochim. Biophys. Acta  274:466-477.

Gordon, A. S., Lombardi, F. J. & Kaback, H. R.  1972. Solubilization and partial purification of amino acid-specific components of the D-lactic dehydrogenase- coupled amino acid transport systems.  Proc. Natl. Acad. Sci. USA 69:358- 362.

Weissbach, H., Thomas, E. & Kaback, H. R. 1971.  Studies on the metabolism of ATP by isolated bacterial membranes:  Formation and metabolism of membrane-bound phosphatidic acid.  Arch. Biochem. Biophys.  147:249-254.

Short, S. A., White, D. C. & Kaback, H. R.  1972.  Active transport in isolated bacterial membrane vesicles.  V. The transport of amino acids by membrane vesicles prepared from Staphylococcus aureus.  J. Biol. Chem. 247:298-304.

Kerwar, G. K., Gordon, A. S. & Kaback, H. R.  1972.  Mechanism of active transport in isolated membrane vesicles.  IV.  Galactose transport by isolated membrane vesicles from Escherichia coli .  J. Biol. Chem.  247:291-297.

Konings, W. N., Barnes, E. M., Jr. & Kaback, H. R.  1971.  Mechanisms of active transport in isolated membrane vesicles.  III.  The couplings of reduced phenazine methosulfate to the concentrative uptake of b-galactosides   and amino acids.  J. Biol. Chem. 246:5857-5861.

Kaback, H. R. & Barnes, E. M., Jr.  1971.  Mechanisms of active transport in isolated membrane vesicles.  II.  The mechanism of energy-coupling between D-lactic dehydrogenase and b-galactoside transport in membrane  preparations.  J. Biol. Chem. 246:5523-5531.

Barnes, E. M., Jr. & Kaback, H. R.  1971.  Mechanism of active transport in isolated membrane vesicles.  I.  The site of energy-coupling between D-lactic dehydrogenase and b-galactoside transport in Escherichia coli membrane  vesicles.  J. Biol. Chem. 246:5518-5522.

Kaback, H. R., Barnes, E. M., Jr. & Milner, L. S.  1971.  Sugar and amino acid transport in isolated bacterial membrane vesicles.  In:  Advances in Microbiology (Libreria Internacional, S.A., Mexico) p. 171.

Barnes, E. M., Jr. & Kaback, H. R.  1970.  b-Galactoside transport in bacterial membrane preparations:  Energy coupling via membrane-bound D-lactic dehydrogenase.  Proc. Natl. Acad. Sci. USA  66:1190-1198.

Kaback, H. R. & Milner, L. S.  1970.  The relationship of a membrane-bound D-(-)-lactic dehydrogenase to amino acid transport in isolated bacterial membranes.  Proc. Natl. Acad. Sci. USA  66:1008-1015.

Kaback, H. R.  1971.  Bacterial membranes. Methods Enzymol. 22:99-120.

Milner, L. S. & Kaback, H. R.  1970.  The role of phosphatidylglycerol in the vectorial phosphorylation of sugar by isolated bacterial membranes.  Proc. Natl. Acad. Sci. USA  65:683-690.

Kaback, H. R.  1970.  Sugar transport in bacteria.  In:  Current Topics in Membranes and Transport Bronner, F. &Kleinzeller, A., eds.  (Academic Press, Inc., New York, NY) p. 35-99.

Kaback, H. R.  1970.  Transport.  Ann. Rev. Biochem. 39:561-598.

Weissbach, H., Redfield, B & Kaback, H. R.  1969.  Nucleotide binding by Escherichia coli  membranes and solubilized membrane proteins Arch. Biochem. Biophys. 135: 66-74.

Kaback, H. R.  1969.  Studies on sugar transport by isolated bacterial membranes.  In:  The Molecular Basis of Membrane Function Tosteson, D., ed.  (Prentice Hall, Inc., Englewood Cliffs, NJ) p. 421-444.

Kaback, H. R.  1969.  Regulation of sugar transport in isolated bacterial membrane preparations from Escherichia coli.  Proc. Natl. Acad. Sci. USA 63:724-731.

Kaback, H. R. & Deuel, T. F.  1969.  Proline uptake by disrupted membrane preparations from Escherichia coli. Arch. Biochem. Biophys. 132:118-129.

Kaback, H. R.  1968.  The role of the phosphoenolpyruvate-phosphotransferase system in the transport of sugars by isolated membrane preparations of Escherichia coli .  J. Biol. Chem. 243:3711-3724.

Kaback, H. R. & Stadtman, E. R.  1968.  Glycine uptake in Escherichia coli .  II. Glycine uptake, exchange, and metabolism by an isolated membrane preparation. J. Biol. Chem. 243:1390-1400.

Kaback, H. R. & Kostellow, A. B.  1968.  Glycine uptake in Escherichia coli .  I.  Glycine uptake by whole cells of Escherichia coli  W+ and a D-serine-resistant  mutant.  J. Biol. Chem. 243:1384-1389.

Kaback, H. R. & Stadtman, E. R.  1966.  Proline uptake by an isolated cytoplasmic membrane preparation of Escherichia coli .  Proc. Natl. Acad. Sci.  USA  55:920-927.

Morrill, G. A., Kaback, H. R. & Robbins, E.  1964.  Effect of calcium on intracellular sodium and potassium concentrations in plant and animal cells.  Nature  204:641-642.

Santer, M., Margulies, N., Klineman, N. & Kaback, H. R.  1960.  Role of inorganic phosphate in thiosulfate metabolism by Thiobacillus thiolarus.  J. Bact. 79:313.

 

 

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